Which growth standards should be used to identify large- and small-for-gestational age infants of mothers with type 1 diabetes? A pre-specified analysis of the CONCEPTT trial

Table 3 Association of adverse neonatal outcomes with their positive and negative predictive values for the INTERGROWTH and WHO criteria. GROW: gestation related optimum weight; NICU: neonatal intensive care unit; WHO: world health organisation. Composite outcome: birth injury, neonatal hypoglycaemia, hyperbilirubinaemia, respiratory distress syndrome, or neonatal intensive care admission; sen: sensitivity; spe: specificity; ppv: positive predictive value; npv: negative predictive value

	Caesarean delivery				Preterm delivery				Neonatal hypoglycaemia				NICU Admission				Hyperbilirubinaemia				Respiratory Distress				Composite Outcome
	sen	spe	ppv	npv	sen	spe	ppv	npv	sen	spe	ppv	npv	sen	spe	ppv	npv	sen	spe	ppv	npv	sen	spe	ppv	npv	sen	spe	ppv	npv
Birthweight > 84.1st centile (mean + 1 sd)
GROW > 84.1st centile	71	49	75	43	66	36	40	62	75	39	29	82	72	39	41	71	74	39	32	80	79	36	10	95	73	42	53	63
INTERGROWTH > 84.1st centile	81	40	75	48	75	26	40	62	81	28	28	81	77	27	38	67	77	27	29	76	79	26	9	93	78	29	50	59
WHO > 84.1st centile	43	77	80	38	22	54	24	52	44	66	30	78	36	63	37	63	31	61	23	70	32	63	7	91	36	64	48	52
Birthweight >90th centile (mean + 1.28 sd)
GROW >90th centile	68	51	76	42	66	40	42	65	75	42	31	84	71	43	42	72	73	42	32	80	79	39	11	95	72	47	55	65
INTERGROWTH >90th centile	72	46	75	43	66	33	39	60	77	37	29	83	75	38	41	72	74	36	31	79	79	34	10	95	74	40	53	63
WHO >90th centile	36	84	84	37	17	62	22	53	39	73	33	78	30	70	37	63	26	69	24	71	21	69	6	91	31	71	49	53
Birthweight > 97.7th centile (mean + 2 sd)
GROW > 97.7th centile	50	76	82	41	51	63	47	66	63	65	38	84	54	65	47	71	53	62	35	78	58	59	12	94	52	67	59	61
INTERGROWTH > 97.7th centile	48	76	82	40	43	60	41	62	61	66	38	83	51	65	46	69	45	61	30	74	53	60	11	93	50	67	58	59
WHO > 97.7th centile	14	90	75	32	9	85	29	59	25	92	50	78	18	91	54	65	11	87	25	72	16	88	11	92	16	91	61	54
GROW <10th centile	3	99	80	31	3	99	60	61	2	98	20	75	4	99	60	64	5	99	60	73	5	98	20	92	3	98	60	53
INTERGROWTH <10th centile	2	100	100	32	2	99	67	61	0	98	0	74	2	99	67	64	3	99	67	73	5	99	33	92	2	99	67	53
WHO <10th centile	10	94	80	32	18	97	80	64	11	92	30	75	16	95	65	66	15	93	45	74	26	93	25	93	14	96	75	55
GROW <25th centile	7	97	85	32	8	96	54	61	4	93	15	74	6	94	38	63	8	95	38	73	11	95	15	92	5	93	38	52
INTERGROWTH <25th centile	3	97	71	31	4	98	57	61	2	96	14	74	5	98	57	64	6	98	57	73	11	98	29	92	4	97	57	53
WHO <25th centile	18	87	76	32	31	93	76	68	19	85	30	76	27	89	59	68	26	87	43	76	37	85	19	94	24	91	70	57

ISSN: 1471-2393