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Table 5 Adjusted Odds Ratio of adverse neonatal outcomes associated with alcohol use during pregnancy identified as a risk factor

From: Maternal alcohol use, adverse neonatal outcomes and pregnancy complications in British Columbia, Canada: a population-based study

ICD-10 Code

Description

Odds Ratio

Adjusted Odds Ratioa

Lower 95% CI

Upper 95% CI

p-value

P04.3

Fetus and newborn affected by maternal use of alcohol

135.84

55.93

21.11

158.32

< 0.001**

P05.9

Slow fetal growth, unspecifiedb

1.40

1.07

0.79

1.41

0.648

P07.1

Other low birth weight (1000-2499 g)

1.64

1.25

1.01

1.53

0.033*

P22.0

Respiratory distress syndrome

1.29

1.01

0.62

1.56

0.95

P24.0

Neonatal aspiration of meconium

0.76

0.72

0.22

1.71

0.52

P22.8

Other respiratory distress of newborn

2.72

2.57

1.52

4.07

< 0.001**

P22.9

Respiratory distress of newborn, unspecified

1.22

0.98

0.64

1.42

0.90

P28.5

Respiratory failure of newborn

1.05

0.90

0.68

1.16

0.419

P28.9

Respiratory condition of newborn, unspecified

1.94

0.56

0.03

2.61

0.577

P29.9

Cardiovascular disorder originating in perinatal period, unspecified

0.00

0.00

N/A

N/A

0.97

P36

Bacterial sepsis of newborn

2.10

1.66

0.74

3.21

0.17

P90

Convulsions of newborn

2.69

1.58

0.47

3.92

0.385

P92.5

Neonatal difficulty in feed at breast

2.61

1.97

1.27

2.92

0.001*

P92.8

Other feeding problems of newborn

0.88

0.67

0.40

1.05

0.10

P92.9

Feeding problems, unspecified

2.53

2.06

1.31

3.09

< 0.001**

P94.1

Congenital hypertonia

0.00

0.00

N/A

N/A

0.99

P96.1

Neonatal withdrawal symptoms from maternal use of drugs of addiction

3.90

0.37

0.21

0.60

< 0.001**

P96.8

Other specified conditions originating in the perinatal period

3.07

2.02

0.70

4.58

0.13

Q05.9

Spina bifida, unspecified

0.00

0.00

N/A

N/A

1.00

Q24.9

Congenital malformations of heart, unspecified; includes anomaly or disease

2.19

5.34

0.30

25.58

0.100

Q35.9

Cleft palate, unspecified

1.58

1.42

0.08

7.08

0.74

Q36

Cleft lip without cleft palate

2.50

2.30

0.13

11.69

0.43

Q37

Cleft lip with cleft palate

1.21

1.02

0.06

4.87

0.98

Q86.0

Fetal alcohol syndrome (dysmorphic)

59.97

10.62

0.36

13.05

0.100

Q89.7

Multiple congenital malformations, not elsewhere classified

18.00

15.63

1.99

79.37

0.003*

Q89.9

Congenital malformation, unspecified

0.00

0.00

N/A

N/A

0.990

R25.1

Tremor, unspecified

2.64

1.46

0.08

7.38

0.718

R62.8

Other lack of expected normal physiological development; includes: failure to gain weight, failure to thrive, infantilism NOS, lack of growth & physical retardation

0.00

0.00

N/A

N/A

0.990

R68.1

Nonspecific symptoms peculiar to infancy; includes: excessive crying of infant & irritable infant

0.00

0.00

N/A

6.78

0.975

  1. aadjusted for maternal age, maternal smoking status, any maternal substance use, parity, prior neonatal deaths, prior stillbirth and prior low birthweight newborn, maternal history of any mental illness and the number of antenatal visits
  2. bincludes: fetal growth restriction NOS, Intrauterine fetal growth restriction, light for dates, light for gestational age (usually referred to weight below but length above 10th percentile), small and light for dates, small for dates, small for gestational (usually referred to weight and length below 10th percentile)
  3. *Significance of produced odds ratio has alpha = p < 0.05
  4. **Significance of produced odds ratio has alpha = p < 0.001
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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