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Table 2 Comparisons of the clinical data from three groups of gestational hypertension according to the gestational age

From: Association between thyroid dysfunction and perinatal outcomes in women with gestational hypertension: a retrospective study

Characteristics

PIH (N = 30)

EPE (N = 57)

LPE (N = 48)

PIH vs. EPE

PIH vs. LPE

EPE vs. LPE

Age (year, mean ± SD)

30.43 ± 4.99

31.61 ± 5.34

31.34 ± 4.78

P = 0.304

P = 0.445

P = 0.785

Gestational weeks (at delivery) (week, mean ± SD)

38.53 ± 1.53

32.70 ± 3.95

38.01 ± 1.82

P < 0.001

P = 0.454

P < 0.001

Sex of baby (male, n%)

60.9% (14/23)

48.9% (23/47)

58.1% (25/43)

P = 0.348

P = 0.830

P = 0.382

Neonatal birth weight (g, mean ± SD)

3192.41 ± 629.84

(N = 29)

1989.09 ± 712.97

(N = 44)

3028.48 ± 591.00

(N = 46)

P < 0.001

P = 0.288

P < 0.001

Hematocrit (L/L, mean ± SD)

0.38 ± 0.03

0.37 ± 0.03

0.37 ± 0.04

P = 0.795

P = 0.164

P = 0.175

Hemoglobin (g/L, mean ± SD)

123.40 ± 9.36

123.91 ± 12.03

119.83 ± 14.84

P = 0.857

P = 0.227

P = 0.102

Platelet (10^9/L, mean ± SD)

220.53 ± 40.22

208.10 ± 58.23

182.95 ± 66.72

P = 0.588

P = 0.011

P = 0.154

Fibrinogen (g/L, mean ± SD)

4.06 ± 0.74

3.67 ± 0.88

3.88 ± 0.64

P = 0.031

P = 0.338

P = 0.169

D-Dimer (mg/L, medians and interquartile ranges)

1.67 (1.16–2.82)

1.81 (1.09–2.39)

1.87 (1.27–2.66)

P = 0.390

P = 0.966

P = 0.371

Brain natriuretic peptide (pg/mL, medians and interquartile ranges)

26.50 (17.25–65.50)

78.50 (25.75–228.00)

84 (32–186)

P = 0.010

P = 0.005

P = 0.993

FT3 (pg/mL, medians and interquartile ranges)

3.56 (2.78–5.93)

3.48 (2.82–4.62)

4.32 (3.10–5.37)

P = 0.659

P = 0.621

P = 0.105

FT4 (ng/dL, medians and interquartile ranges)

6.23 ± 1.06

6.21 ± 1.69

6.00 ± 1.89

P = 1.000

P = 0.885

P = 0.925

TSH (mIU/L, medians and interquartile ranges)

2.92 ± 0.93

2.64 ± 1.43

2.62 ± 1.26

P = 0.366

P = 0.347

P = 0.923

Triglyceride (mmol/L, medians and interquartile ranges)

1.95 ± 0.38

1.71 ± 0.82

1.77 ± 0.75

P = 0.165

P = 0.300

P = 0.730

Total cholesterol (mmol/L, mean ± SD)

2.54 (2.24–2.68)

2.49 (2.26–2.76)

2.55 (2.35–2.70)

P = 0.989

P = 0.569

P = 0.518

Low density lipoprotein (mmol/L, mean ± SD)

0.98 (0.90–1.06)

0.95 (0.85–1.06)

0.93 (0.83–1.05)

P = 0.655

P = 0.229

P = 0.477

High density lipoprotein (mmol/L, mean ± SD)

2.32 (1.79–3.26)

2.61 (1.63–4.20)

2.18 (1.67–3.05)

P = 0.748

P = 0.534

P = 0.433

Rate of preterm birth (n%)

7.1% (2/28)

84.1% (37/44)

15.6% (7/45)

P < 0.001

P = 0.486

P < 0.001

Rate of abortion (n%)

0

2.1% (1/48)

0

NS

NS

NS

Rate of induced labor (n%)

0

4.2% (2/48)

0

NS

NS

NS

Rate of fetal death (n%)

0

2.1% (1/48)

2.2% (1/46)

NS

NS

P = 0.315

Thyroid dysfunction (n%)

60% (18/30)

71.9% (41/57)

56.3% (27/48)

P = 0.258

P = 0.744

P = 0.094

Hypothyroidism (n%)

0

10.5% (6/57)

4.2% (2/48)

NS

NS

P = 0.162

Subclinical hypothyroidism (n%)

20% (6/30)

15.8% (9/57)

8.3% (4/48)

P = 0.804

P = 0.284

P = 0.072

FT3 under the lower limit (n%)

6.7% (2/30)

10.5% (6/57)

2.1% (1/48)

P = 0.514

P = 0.680

P = 0.072

FT4 under the lower limit (n%)

16.7% (5/30)

19.3% (11/57)

25% (12/48)

P = 0.339

P = 0.623

P = 0.556

FT3 and FT4 both under the lower limit (n%)

6.7% (2/30)

7.0% (4/57)

10.4% (5/48)

P = 0.909

P = 1.000

P = 1.000

Hashimoto thyroiditis (n%)

13.3% (4/30)

8.8% (5/57)

4.2% (2/48)

P = 1.000

P = 0.303

P = 0.267

hyperthyroidism (n%)

0

3.5% (2/57)

2.1% (1/48)

NS

NS

P = 0.773

  1. A nominal 2-sided probability value < 0.05 was considered to indicate statistical significance, and adjustments were made for multiple comparisons in chi-square test and Kruskal Wallis Test (Padjust < 0.017)
  2. PIH pregnant induced hypertension; EPE early onset preeclampsia; LPE late onset preeclampsia; FT3 free triiodothyronine; FT4 free thyroxine; TSH thyrotropic hormone