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Table 1 Comparisons of the clinical data from three groups of gestational hypertension according to the severity of the disease

From: Association between thyroid dysfunction and perinatal outcomes in women with gestational hypertension: a retrospective study

Characteristics

PIH (N = 30)

MPE (N = 20)

SPE (N = 85)

PIH vs. MPE

PIH vs. SPE

MPE vs. SPE

Age (year, mean ± SD)

30.43 ± 4.99

31.65 ± 4.44

31.45 ± 5.23

P = 0.407

P = 0.346

P = 0.876

Gestational weeks (at delivery) (week, mean ± SD)

38.53 ± 1.53

38.16 ± 2.37

34.42 ± 4.13

P = 0.899

P < 0.001

P < 0.001

Sex of baby (male, n%)

60.9% (14/23)

50% (8/16)

54.1% (40/74)

P = 0.730

P = 0.566

P = 0.768

Neonatal birth weight (g, mean ± SD)

3192.41 ± 629.84

(N = 29)

3134.21 ± 720.14

(N = 19)

2356.06 ± 787.95

(N = 71)

P = 0.791

P < 0.001

P < 0.001

Hematocrit (L/L, mean ± SD)

0.38 ± 0.03

0.37 ± 0.02

0.37 ± 0.04

P = 0.853

P = 0.328

P = 0.534

Hemoglobin (g/L, mean ± SD)

123.40 ± 9.36

123.90 ± 8.43

121.63 ± 14.41

P = 0.892

P = 0.514

P = 0.474

Platelet (10^9/L, mean ± SD)

220.53 ± 40.22

204.90 ± 45.86

194.38 ± 67.10

P = 0.524

P = 0.047

P = 0.797

Fibrinogen (g/L, mean ± SD)

4.06 ± 0.74

3.93 ± 0.63

3.73 ± 0.81

P = 0.575

P = 0.052

P = 0.301

D-Dimer (mg/L, medians and interquartile ranges)

1.67 (1.16–2.82)

1.76 (1.07–2.97)

1.84 (1.20–2.41)

P = 0.823

P = 0.607

P = 0.877

Brain natriuretic peptide (pg/mL, medians and interquartile ranges)

26.50 (17.25–65.50)

40 (21–90)

84.5 (34.75–231.25)

P = 0.265

P = 0.002

P = 0.075

FT3 (pg/mL, medians and interquartile ranges)

2.54 (2.24–2.69)

2.65 (2.52–2.89)

2.49 (2.26–2.70)

P = 0.040

P = 0.767

P = 0.014

FT4 (ng/dL, medians and interquartile ranges)

0.98 (0.90–1.06)

0.98 (0.86–1.06)

0.93 (0.85–1.06)

P = 0.992

P = 0.286

P = 0.311

TSH (mIU/L, medians and interquartile ranges)

2.32 (1.79–3.26)

2.09 (1.65–2.96)

2.58 (1.76–3.74)

P = 0.342

P = 0.881

P = 0.361

Triglyceride (mmol/L, medians and interquartile ranges)

3.56 (2.78–5.93)

4.15 (2.83–4.80)

3.98 (2.85–4.94)

P = 1.000

P = 0.974

P = 0.947

Total cholesterol (mmol/L, mean ± SD)

6.23 ± 1.06

5.25 ± 1.69

6.28 ± 1.75

P = 0.150

P = 0.998

P = 0.121

Low density lipoprotein (mmol/L, mean ± SD)

2.92 ± 0.93

2.15 ± 1.08

2.72 ± 1.39

P = 0.064

P = 0.490

P = 0.114

High density lipoprotein (mmol/L, mean ± SD)

1.95 ± 0.38

1.59 ± 0.73

1.76 ± 0.80

P = 0.126

P = 0.241

P = 0.408

Rate of preterm birth (n%)

7.1% (2/28)

15.8% (3/19)

58.6% (41/70)

P = 0.644

P < 0.001

P = 0.001

Rate of abortion (n%)

0

0

1.3% (1/75)

NS

NS

NS

Rate of induced labor (n%)

0

0

2.7% (2/75)

NS

NS

NS

Rate of fetal death (n%)

0

0

2.7% (2/75)

NS

NS

NS

Thyroid dysfunction (n%)

60% (18/30)

40% (8/20)

70.6% (60/85)

P = 0.166

P = 0.286

P = 0.010

Hypothyroidism (n%)

0

0

9.4% (8/85)

NS

NS

NS

Subclinical hypothyroidism (n%)

20% (6/30)

15% (3/20)

11.8% (10/85)

P = 0.748

P = 0.622

P = 0.988

FT3 under the lower limit (n%)

6.7% (2/30)

0

8.2% (7/85)

NS

P = 0.847

NS

FT4 under the lower limit (n%)

16.7% (5/30)

20% (4/20)

22.4% (19/85)

P = 1.000

P = 0.324

P = 0.330

FT3 and FT4 both under the lower limit (n%)

6.7% (2/30)

5% (1/20)

9.4% (8/85)

P = 1.000

P = 0.709

P = 0.517

Hashimoto thyroiditis (n%)

13.3% (4/30)

10% (2/20)

5.9% (5/85)

P = 0.66

P = 0.69

P = 1

hyperthyroidism (n%)

0

0

3.5% (3/85)

NS

NS

NS

  1. A nominal 2-sided probability value < 0.05 was considered to indicate statistical significance, and adjustments were made for multiple comparisons in chi-square test and Kruskal Wallis Test (Padjust < 0.017)
  2. PIH pregnant induced hypertension; MPE mild preeclampsia; SPE severe preeclampsia; FT3 free triiodothyronine; FT4 free thyroxine; TSH thyrotropic hormone