Table 1 Participants’ characteristics and screening markers
|  | MS-AFP ≥ 2.5 MoM | MS-AFP < 2.5 MoM | P value |
|---|---|---|---|
Maternal age (years) | 30.55 ± 4.43 | 30.99 ± 4.36 | 0.139 |
Maternal age ≥ 35 years (n, %) | 35 (14.58) | 571 (18.51) | 0.129 |
Maternal weight (kg) | 55.65 ± 9.31 | 55.63 ± 8.59 | 0.980 |
Maternal height (cm) | 160.09 ± 5.10 | 160.40 ± 4.80 | 0.353 |
Body mass index | 21.66 ± 3.44 | 21.61 ± 3.12 | 0.823 |
Neonatal gender (male/female) | 114/126 | 1546/1439 | 0.435 |
Parity (2/1/0) | 68/78/94 | 755/1028/1302 | 0.392 |
Smoking history (n, %) | 0 (0.00) | 8 (0.26) | 1.000 |
Gestational diabetes mellitus (n, %) | 26 (10.83) | 293 (9.50) | 0.499 |
Assisted reproductive technology (n, %) | 14 (5.83) | 78 (2.53) | 0.003 |
Caesarean section (n, %) | 104 (43.33) | 1264 (40.97) | 0.474 |
Forceps delivery (n, %) | 6 (2.50) | 58 (1.88) | 0.501 |
NT MoM (median, IQR) | 0.95 (0.80~1.13) | 0.98 (0.83~1.17) | 0.105 |
β-HCG MoM (median, IQR) | 0.98 (0.60~1.62) | 1.01 (0.63~1.62) | 0.430 |
PAPP-A MoM (median, IQR) | 0.91 (0.68~1.27) | 0.99 (0.73~1.37) | 0.001 |
AFP MoM (median, IQR) | 2.97 (2.67~3.53) | 1.03 (0.76~1.58) | 0.000 |