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Fig. 9 | BMC Pregnancy and Childbirth

Fig. 9

From: Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling

Fig. 9

CXCL12 stimulated the migration and invasion of EECs by activating AKT/ PI3K signaling. Exogenous CXCL12 significantly increased the migration and invasion of EECs in vitro, which effect was remarkably inhibited by neutralizing antibodies to CXCR4 or PI3K/AKT blocker (LY294002). The ERK1/2 blocker (U0126) failed to block the CXCL12-induced EEC migration or invasion. * P < 0.05, ** P < 0.01 vs. control; # P < 0.05, ## P < 0.01 vs. CXCL12-treated or EEC-CM-treated group. Data are presented as mean ± SD. (n = 3). EEC: human first-trimester endometrial epithelial cell. EEC-CM: EEC conditioned medium

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