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Fig. 8 | BMC Pregnancy and Childbirth

Fig. 8

From: Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling

Fig. 8

CXCL12 stimulated the activation of Akt, PI3K, and ERK in EECs by binding to CXCR4. The phosphorylation of protein kinase B (AKT) and extracellular regulated protein kinases (ERK) in human first-trimester endometrial epithelial cells (EECs) was inhibited by treatment with CXCR4 neutralizing antibody, LY294002 (a PI3K/AKT blocker) or U0126 (a ERK1/2 blocker). Phosphorylated proteins were stained in green and total proteins were stained in red. The phosphorylated to total protein ratio was normalized to 1 in the untreated control (n = 3)

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