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Fig. 5 | BMC Pregnancy and Childbirth

Fig. 5

From: Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling

Fig. 5

EEC-derived CXCL12 induced EEC migration by binding to CXCR4 a Exogenous CXCL12 significantly increased EEC migration in vitro, whereas neutralizing antibodies against CXCR4 or CXCL12 effectively inhibited the CXCL12-induced migration of EECs. b EEC-CM significantly increased EEC migration in vitro, and a neutralizing antibody against CXCR4 or CXCL12 effectively inhibited the EEC-CM-induced migration of EECs. c CXCR4 or CXCL12 blocking antibody alone could markedly inhibit the migration of EECs. * P < 0.05, ** P < 0.01 vs. control; # P < 0.05, ## P < 0.01, vs. CXCL12-treated or EEC-CM treated group. Data are presented as mean ± SD (n = 3). EEC: human first-trimester endometrial epithelial cell, EEC-CM: EEC conditioned culture medium

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