NICE hypertension in pregnancy recommendations | P-value1 | P-value2 (CI) | ||
---|---|---|---|---|
Before guidance N = 1271 | After guidance N = 1219 | |||
Gestational hypertension or pre-eclampsiaa | 227 (18) | 195 (16) | 0.20 | 0.18 (− 0.05, 0.01) |
Blood pressure equal or exceeding recommended treatment thresholdb | 54 (24) | 62 (32) | 0.60 | < 0.07 (− 0.17, 0.01) |
Antihypertensive prescription (for gestational hypertension and Pre-eclampsia): | N = 227 | N = 195 | < 0.01 | |
No antihypertensive | 139 (62) | 53 (27) | < 0.01 (−0.44, − 0.26) | |
Labetalol | 58 (26) | 120 (62) | < 0.01 (0.27, 0.45) | |
Other antihypertensive prescribedc | 28 (12) | 22 (11) | 0.75 (−0.07, 0.05) | |
Missing | 2 (< 1) | – | – | |
Protein estimated when hypertension identified | 156 (68) | 148 (76) | 0.80 | 0.07 (−0.01, 0.17) |
Method used to estimate protein: | N = 156 | N = 148 | < 0.01 | |
24 h urine | 13 (8) | 6 (4) | 0.14 (−0.09, 0.01) | |
Automated reagent strip reading | 6 (4) | 17 (11) | 0.02 (0.01, 0.13) | |
Spot PCR | 47 (30) | 98 (66) | < 0.01 (0.26, 0.46) | |
Reagent strip visual inspection | 67 (43) | 26 (18) | ||
Other estimation | 19 (12) | 1 (< 1) | – | |
Unclear | 3 (2) | – | – | |
Missing | 1 (< 1) | – | – | |
Admitted due to HDP | 92 (56) | 127 (65) | < 0.01 | < 0.001 (0.14, 0.33) |
Care on hospital admission: | N = 92 | N = 127 | ||
Highest mean systolic blood pressure prior to admission (for HDP) | 150 | 155 | < 0.01 (−9.3, −1.4) | – |
Highest mean diastolic blood pressure prior to admission (for HDP) | 98 | 114 | 0.19 (−40.7, 8.1) | – |
Protein estimated prior to admission | 67 (73) | 92 (72) | 0.70 | 0.87 (− 0.13, 0.11) |
Anti-hypertensive prescribedc | 46 (50) | 79 (62) | 0.02 | 0.08 (−0.01, 0.25) |
Existing hypertensive medication increased | 8 (9) | 19 (15) | 0.18 (−0.03, 0.15) | |
No medication prescribed or increased | 36 (39) | 29 (22) | 0.01 (−0.29, 0.05) | |
Labetalol prescribed | 35 (38) | 64 (50) | 0.07 (−0.01, 0.25) | |
Labetalol increased | 5 (5) | 21 (17) | 0.01 (0.04, 0.20) | |
Other antihypertensive prescribedd | 14 (15) | 13 (10) | 0.26 (−0.13, 0.04) | |
For all women with a HDP diagnosis: | N = 227 | N = 195 | ||
Was early Birth < 37 weeks gestation offered due to HDP~ | 20 (9) | 35 (18) | 0.01 | 0.01 (0.02, 0.16) |
If early Birth < 37 weeks gestation offered due to HDP: | N = 20 | N = 35 | 0.20 | |
Was blood pressure ≥ 160/110 | 1 (5) | 5 (14) | 0.30 (−0.06, 0.24) | |
No evidence of BP ≥ 160/110 | 9 (45) | 8 (23) | 0.09 (−0.48, 0.04) | |
‘Other’ concerns | 10 (50) | 22 (63) | 0.35 (−0.14, 0.40) | |
For all women with a HDP diagnosis: | N = 227 | N = 195 | ||
Was early Birth ≥ 37 weeks gestation offered due to HDP | 68 (30) | 103 (52) | < 0.01 | < 0.01 (0.09, 0.35) |
If early Birth ≥ 37 weeks gestation offered due to HDP: | N = 68 | N = 103 | < 0.01 | |
Blood pressure ≥ 160/110 | 8 (12) | 5 (5) | 0.10 (−0.16, 0.02) | |
No evidence of BP ≥ 160/110 | 54 (79) | 60 (58) | < 0.01 (−0.35, − 0.07) | |
‘Other’ concerns | 6 (9) | 38 (37) | < 0.01 (0.16, 0.40) |