Table 4 Incremental costs ($, 2017 prices) and outcomes (diagnostic rate), and incremental cost-effectiveness ratios for the proposed algorithm versus the current algorithm
Proposed algorithm (n = 130) | Current algorithm (n = 130) | Difference | |
|---|---|---|---|
Primary analysis: assuming 100% of the patients are willing to pay for out-of-pocket aCGH | |||
Outcome: | |||
Number of diagnosis | 39 | 39 | 0 |
Diagnostic rate (%) | 30.0 | 30.0 | 0.0 (−12.3 to 10.2) |
Total healthcare costs ($) | |||
Total costs | 412,100 | 639,600 | − 227,500 |
Total cost per sample | 3170 | 4920 | − 1750 (95% CI: − 2395 to − 1098) |
Total cost per diagnosis ($/dx) | 10,567 | 16,400 | −5833 |
Total societal costs ($) | |||
Total costs | 911,900 | 1,139,400 | −227,500 |
Total cost per sample | 7015 | 8765 | −1750 (95% CI: −2545 to −817) |
Total cost per diagnosis ($/dx) | 23,382 | 29,215 | −5833 |
Healthcare system perspective: Cost per one additional diagnosis (ICER) | Proposed algorithm dominates | ||
Societal perspective: Cost per one additional diagnosis (ICER) | Proposed algorithm dominates | ||
Secondary analysis: only 41.8% of the patients are willing to pay for out-of-pocket aCGH | |||
Outcome: | |||
Number of diagnosis | 32 | 30 | 0 |
Diagnostic rate (%) | 24.6 | 23.1 | 1.5 (−10.4 to 11.7) |
Total healthcare costs ($) | |||
Total costs | 309,665 | 510,465 | −200,800 |
Total cost per sample | 2382 | 3927 | −1545 (95% CI:-2030 to −1095) |
Total cost per diagnosis ($/dx) | 9677 | 18,231 | −7339 |
Total societal costs ($) | |||
Total costs | 515,465 | 716,265 | −200,800 |
Total cost per sample | 3965 | 5510 | −1545 (95% CI: −2407 to −706) |
Total cost per diagnosis ($/dx) | 16,108 | 23,876 | −7768 |
Healthcare system perspective: Cost per one additional diagnosis (ICER) | Proposed algorithm dominates | ||
Societal perspective: Cost per one additional diagnosis (ICER) | Proposed algorithm dominates | ||