Cost-effectiveness analysis of chromosomal microarray as a primary test for prenatal diagnosis in Hong Kong

Table 1 Cost breakdown of each technology per sample

–	QF-PCR	aCGH /Parental aCGH	AF/CV karyotyping	Blood karyotyping	FISH	MLPA	Other PCR molecular study
–	Cost per sample (HKD $)
Staff	927	2281	1850	1490	1715	1743	687
Reagents and consumables	128	1847	196	196	304	2100	280
Major equipment ^a	7	169	90	90	137	175	7
Overheads	215	580	314	174	364	918	193
Other costs	23	23	50	50	80	64	33
Total	1300	4900	2500	2000	2600	5000	1200

^a Major equipment for QF-PCR includes: DNA fragment analyzer, thermal cycler, and centrifuge. Major equipment for aCGH and parental aCGH includes: microarray scanner, incubator, thermal cycler, spectrophotometer, gel electrophoresis, gel image documentation, and centrifuge. Major equipment for conventional cytogenetics (AF/CV/Blood karyotyping) includes: CytoVision, biosafety cabinets, CO₂ incubator, and centrifuge. Major equipment for FISH includes fluorescent microscope, thermal hybridizer, and centrifuge. Major equipment for MLPA and other molecular study includes: DNA fragment analyzer, thermal cycler, and centrifuge
aCGH array comparative genomic hybridization, AF/CV amniotic fluid/chorionic villus, FISH fluorescence in-situ hybridization, MLPA multiplex-ligation dependent probe amplification, QF-PCR quantitative fluorescent polymerase chain reaction

ISSN: 1471-2393