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Table 5 Mediation analysis of the association between ART and child-health outcomes mediated by multiple pregnancies

From: Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study

G-Computation estimate

Total effect

β (95%CI)

p

Natural direct effect

β (95%CI)

p

Natural indirect effect

β (95%CI)

p

Mediated effect (%)

Gestational age at delivery (weeks)

−1.29 (−2.22; −0.38)

0.006*

−0.10 (−0.82; 0.63)

0.79

−1.20 (−2.04; − 0.36)

0.005*

92%

Birthweight (g)

− 302.2 (− 593.7; − 10.7)

0.04*

27.8 (− 145.6; 201.2)

0.75

− 330.1 (−571.3; −88.8)

0.007*

92%

Length at birth (cm)

− 0.82 (− 1.79; 016)

0.10

0.06 (− 0.59; 0.71)

0.85

− 0.88 (− 1.50; − 0.26)

0.006*

94%

Head circumference at birth (cm)

− 0.82 (− 1.78; 0.15)

0.10

0.05 (− 0.60; 0.70)

0.88

− 0.87 (− 1.49; − 0.24)

0.006*

95%

  1. CI confidence interval. *p < 0.05
  2. *Adjusted for base confounders maternal age, family income, maternal schooling, parity and pre-pregnancy body mass index and for post confounder hospitalization during pregnancy