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Table 3 Risk of bias of included studies (QUADAS 2) and concerns regarding applicability

From: Targeted antenatal anti-D prophylaxis for RhD-negative pregnant women: a systematic review

Study

Patient selection

Index test

Reference standard

Flow and timing

Applicability concerns - total

De Haas 2016

low

unclear

low

high

low

Clausen 2014

low

unclear

unclear

high

low

Haimila 2017

low

unclear

unclear

low

low

Wikman 2012

low

unclear

unclear

high

low

Chitty 2014

unclear

low

unclear

high

low

Finning 2008

unclear

unclear

low

low

low

MĂĽller 2008

low

unclear

unclear

low

low

Macher 2012

low

unclear

unclear

low

low

Hyland 2017

low

unclear

unclear

low

low

Akolekar 2011

unclear

unclear

unclear

low

low

Minon 2008

low

unclear

unclear

low

low

Soothill 2015

low

low

low

low

low