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Table 3 Use of paracetamol and the severity of preeclampsia in cases (n=1,252) and controls (n=1,256).

From: Increased risk of preeclampsia after use of paracetamol during pregnancy – causal or coincidence?

Time of use of paracetamol All n (%) Pre-eclampsia n (%) Controls n (%) Unadjusted OR (95% CL) p-value Adjusted OR (95% CL)a p-value
< 15 GWs 32 (1.3) 19 (1.5) 13 (1.0) 1.48 (0.72–3.01) 0.279 1.48 (0.67–3.24) 0.331
   9 (1.2) mild   1.20 (0.51–2.81) 0.680 1.16 (0.46–2.92) 0.752
   10 (1.9) severe   1.88 (0.82–4.32) 0.136 1.95 (0.79–4.80) 0.146
≥ 15 and < 29 GWs 38 (1.5) 25 (2.0) 13 (1.0) 1.96 (1.00–3.85) 0.051 2.06 (0.95–4.45) 0.067
   13 (1.8) mild   1.74 (0.80–3.77) 0.161 1.89 (0.81–4.45) 0.143
   12 (2.3) severe   2.27 (1.03–5.00) 0.043 2.30 (0.94–5.60) 0.067
≥ 29 GWs 51 (2.0) 45 (3.6) 6 (0.5) 7.81 (3.32–18.37) < 0.001 7.63 (3.14–18.55) < 0.001
   29 (4.0) mild   8.65 (3.57–20.93) < 0.001 8.50 (3.40–21.17) < 0.001
   16 (3.1) severe   6.64 (2.58–17.07) < 0.001 6.36 (2.38–16.94) < 0.001
Unknown 16 (0.6) 11 (0.9) 5 (0.4)     
All paracetamol users 137(5.5) 100 (8.0) 37 (2.9) 2.86 (1.95–4.21) < 0.001 2.84 (1.86–4.32) < 0.001
All women 2508 (100) 1252 (100) 1256 (100)     
  1. CL confidence limits. GWs gestational weeks a) adjusted for maternal age, parity, BMI, smoking, diagnosed hypertension and diabetes or GDM. P-values are estimated by Logistic regression analysis.