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Table 3 Use of paracetamol and the severity of preeclampsia in cases (n=1,252) and controls (n=1,256).

From: Increased risk of preeclampsia after use of paracetamol during pregnancy – causal or coincidence?

Time of use of paracetamol

All n (%)

Pre-eclampsia n (%)

Controls n (%)

Unadjusted OR (95% CL)

p-value

Adjusted OR (95% CL)a

p-value

< 15 GWs

32 (1.3)

19 (1.5)

13 (1.0)

1.48 (0.72–3.01)

0.279

1.48 (0.67–3.24)

0.331

  

9 (1.2) mild

 

1.20 (0.51–2.81)

0.680

1.16 (0.46–2.92)

0.752

  

10 (1.9) severe

 

1.88 (0.82–4.32)

0.136

1.95 (0.79–4.80)

0.146

≥ 15 and < 29 GWs

38 (1.5)

25 (2.0)

13 (1.0)

1.96 (1.00–3.85)

0.051

2.06 (0.95–4.45)

0.067

  

13 (1.8) mild

 

1.74 (0.80–3.77)

0.161

1.89 (0.81–4.45)

0.143

  

12 (2.3) severe

 

2.27 (1.03–5.00)

0.043

2.30 (0.94–5.60)

0.067

≥ 29 GWs

51 (2.0)

45 (3.6)

6 (0.5)

7.81 (3.32–18.37)

< 0.001

7.63 (3.14–18.55)

< 0.001

  

29 (4.0) mild

 

8.65 (3.57–20.93)

< 0.001

8.50 (3.40–21.17)

< 0.001

  

16 (3.1) severe

 

6.64 (2.58–17.07)

< 0.001

6.36 (2.38–16.94)

< 0.001

Unknown

16 (0.6)

11 (0.9)

5 (0.4)

    

All paracetamol users

137(5.5)

100 (8.0)

37 (2.9)

2.86 (1.95–4.21)

< 0.001

2.84 (1.86–4.32)

< 0.001

All women

2508 (100)

1252 (100)

1256 (100)

    
  1. CL confidence limits. GWs gestational weeks a) adjusted for maternal age, parity, BMI, smoking, diagnosed hypertension and diabetes or GDM. P-values are estimated by Logistic regression analysis.