From: Increased risk of preeclampsia after use of paracetamol during pregnancy – causal or coincidence?
Time of use of paracetamol | All n (%) | Pre-eclampsia n (%) | Controls n (%) | Unadjusted OR (95% CL) | p-value | Adjusted OR (95% CL)a | p-value |
---|---|---|---|---|---|---|---|
< 15 GWs | 32 (1.3) | 19 (1.5) | 13 (1.0) | 1.48 (0.72–3.01) | 0.279 | 1.48 (0.67–3.24) | 0.331 |
9 (1.2) mild | 1.20 (0.51–2.81) | 0.680 | 1.16 (0.46–2.92) | 0.752 | |||
10 (1.9) severe | 1.88 (0.82–4.32) | 0.136 | 1.95 (0.79–4.80) | 0.146 | |||
≥ 15 and < 29 GWs | 38 (1.5) | 25 (2.0) | 13 (1.0) | 1.96 (1.00–3.85) | 0.051 | 2.06 (0.95–4.45) | 0.067 |
13 (1.8) mild | 1.74 (0.80–3.77) | 0.161 | 1.89 (0.81–4.45) | 0.143 | |||
12 (2.3) severe | 2.27 (1.03–5.00) | 0.043 | 2.30 (0.94–5.60) | 0.067 | |||
≥ 29 GWs | 51 (2.0) | 45 (3.6) | 6 (0.5) | 7.81 (3.32–18.37) | < 0.001 | 7.63 (3.14–18.55) | < 0.001 |
29 (4.0) mild | 8.65 (3.57–20.93) | < 0.001 | 8.50 (3.40–21.17) | < 0.001 | |||
16 (3.1) severe | 6.64 (2.58–17.07) | < 0.001 | 6.36 (2.38–16.94) | < 0.001 | |||
Unknown | 16 (0.6) | 11 (0.9) | 5 (0.4) | ||||
All paracetamol users | 137(5.5) | 100 (8.0) | 37 (2.9) | 2.86 (1.95–4.21) | < 0.001 | 2.84 (1.86–4.32) | < 0.001 |
All women | 2508 (100) | 1252 (100) | 1256 (100) |