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Table 1 Demographic and clinical features of the study subjects

From: Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

Variables Controls(N = 158) PE (n = 177) EOPE (n = 70) LOPE (n = 107) Pa Value Pb Value Pc Value
Maternal age ( years) 30.00(28.00–33.00) 31.00(28.00–35.00) 33.00(28.00–37.00) 30.00(27.00-33.50) 0.078 0.001* 0.935
Gestation at delivery (weeks) 39.43(38.86–39.86) 35.43(32.57–37.57) 31.86(29.86–33.14) 37.00(35.93–38.43) < 0.001 * < 0.001 * < 0.001 *
Height 162.50(160.00-165.00) 162.00(159.00-165.00) 160.00 158.00-164.00) 162.50(159.50–165.00) 0.648 0.042 0.388
Weight 71.00 (66.00–80.00) 76.00 (70.00–87.00) 75.00(70.00-82.50) 78.00(70.00-89.50) < 0.001 * 0.017 < 0.001 *
BMI 27.34(25.00-29.655) 29.14(26.80–32.80) 28.76(26.71–32.23) 29.30(26.89–33.10) < 0.001 * 0.001* < 0.001 *
TSH(Ulu/mL) 2.06(1.51–2.89) 3.69(2.29–5.19) 3.66(2.21–4.87) 3.69(2.35–5.31) < 0.001 * < 0.001 * < 0.001 *
FT3 4.75(4.17–5.19) 3.91(3.40–4.43) 3.72(3.31–4.21) 4.01(3.45–4.53) < 0.001 * < 0.001 * < 0.001 *
FT4 10.94(9.84–13.13) 11.82(10.37–13.45) 11.32(10.37–13.45) 12.02 (10.59–13.54) 0.019* 0.496 0.004*
TC (mmol/L) 6.06 (5.36–6.95) 6.03 (5.13–7.06) 6.14 (5.27–7.48) 5.98 (5.07-7.00) 0.186 0.806 0.186
TG (mmol/L) 3.05 (2.46–3.96) 3.51 (2.80–4.51) 3.48 (2.65–4.43) 3.57 (2.84–4.54) 0.002 * 0.026 0.002 *
HDL-C (mmol/L) 1.86 (1.65–2.11) 1.71 (1.44–2.05) 1.76(1.49–2.11) 1.68(1.39–1.98) < 0.001 * 0.128 0.001 *
LDL-C (mmol/L) 2.87 (2.42–3.48) 3.02 (2.52–3.72) 3.10 (2.62–3.87) 2.92 (2.40–3.70) 0.460 0.052 0.532
TG/HDL-C 1.74 (1.32–2.24) 2.14 (1.54–2.81) 2.08 (1.52–2.65) 2.19 (1.57–2.90) < 0.001 * 0.006* < 0.001 *
  1. PE represents Preeclampsia, EOPE represents early- onset preeclampsia, LOPE represents late-onset preeclampsia, BMI Body mass index, TSH Thyroid-stimulating hormone, FT3 Free triiodothyronine, FT4 Free thyroxine, TC Total cholesterol, TG Triglyceride, HDL-C High-density lipoprotein, LDL-C Low-density lipoprotein, TG/HDL Triglyceride/ high-density lipoprotein
  2. All the continuous variables were presented as median and the 25th-75th percentile for non-normal distribution tested. P values were analysis using U-test
  3. a PE vs. controls, b EOPE vs. controls, c LOPE vs. controls, Pa < 0.05; * Pb and PC < 0.017 for sub-group