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Table 1 Demographic and clinical features of the study subjects

From: Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

Variables

Controls(N = 158)

PE (n = 177)

EOPE (n = 70)

LOPE (n = 107)

Pa Value

Pb Value

Pc Value

Maternal age ( years)

30.00(28.00–33.00)

31.00(28.00–35.00)

33.00(28.00–37.00)

30.00(27.00-33.50)

0.078

0.001*

0.935

Gestation at delivery (weeks)

39.43(38.86–39.86)

35.43(32.57–37.57)

31.86(29.86–33.14)

37.00(35.93–38.43)

< 0.001 *

< 0.001 *

< 0.001 *

Height

162.50(160.00-165.00)

162.00(159.00-165.00)

160.00 158.00-164.00)

162.50(159.50–165.00)

0.648

0.042

0.388

Weight

71.00 (66.00–80.00)

76.00 (70.00–87.00)

75.00(70.00-82.50)

78.00(70.00-89.50)

< 0.001 *

0.017

< 0.001 *

BMI

27.34(25.00-29.655)

29.14(26.80–32.80)

28.76(26.71–32.23)

29.30(26.89–33.10)

< 0.001 *

0.001*

< 0.001 *

TSH(Ulu/mL)

2.06(1.51–2.89)

3.69(2.29–5.19)

3.66(2.21–4.87)

3.69(2.35–5.31)

< 0.001 *

< 0.001 *

< 0.001 *

FT3

4.75(4.17–5.19)

3.91(3.40–4.43)

3.72(3.31–4.21)

4.01(3.45–4.53)

< 0.001 *

< 0.001 *

< 0.001 *

FT4

10.94(9.84–13.13)

11.82(10.37–13.45)

11.32(10.37–13.45)

12.02 (10.59–13.54)

0.019*

0.496

0.004*

TC (mmol/L)

6.06 (5.36–6.95)

6.03 (5.13–7.06)

6.14 (5.27–7.48)

5.98 (5.07-7.00)

0.186

0.806

0.186

TG (mmol/L)

3.05 (2.46–3.96)

3.51 (2.80–4.51)

3.48 (2.65–4.43)

3.57 (2.84–4.54)

0.002 *

0.026

0.002 *

HDL-C (mmol/L)

1.86 (1.65–2.11)

1.71 (1.44–2.05)

1.76(1.49–2.11)

1.68(1.39–1.98)

< 0.001 *

0.128

0.001 *

LDL-C (mmol/L)

2.87 (2.42–3.48)

3.02 (2.52–3.72)

3.10 (2.62–3.87)

2.92 (2.40–3.70)

0.460

0.052

0.532

TG/HDL-C

1.74 (1.32–2.24)

2.14 (1.54–2.81)

2.08 (1.52–2.65)

2.19 (1.57–2.90)

< 0.001 *

0.006*

< 0.001 *

  1. PE represents Preeclampsia, EOPE represents early- onset preeclampsia, LOPE represents late-onset preeclampsia, BMI Body mass index, TSH Thyroid-stimulating hormone, FT3 Free triiodothyronine, FT4 Free thyroxine, TC Total cholesterol, TG Triglyceride, HDL-C High-density lipoprotein, LDL-C Low-density lipoprotein, TG/HDL Triglyceride/ high-density lipoprotein
  2. All the continuous variables were presented as median and the 25th-75th percentile for non-normal distribution tested. P values were analysis using U-test
  3. a PE vs. controls, b EOPE vs. controls, c LOPE vs. controls, Pa < 0.05; * Pb and PC < 0.017 for sub-group