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Table 4 Comparation of PPV of Trisomy 21, 18, ONTD and other deformity (n ‰)

From: New cut-off values for screening of trisomy 21, 18 and open neural tube defects (ONTD) during the second trimester in pregnant women with advanced maternal age

Group n High risk Low risk Sum
Trisomy 21 Trisomy 18 ONTD Other deformity Trisomy 21 Trisomy 18 ONTD Other deformity Trisomy 21 Trisomy 18 ONTD Other deformity
Non-AMA 197,101 24(0.12‰) 10(0.05‰) 4(0.02‰) 202(1.02‰) 24(0.12‰) 5(0.03‰) 10(0.05‰) 1445(7.33‰) 48(0.24‰) 15(0.08‰) 14(0.07‰) 1647(8.36‰)
AMA 12,739 20(1.57‰) 1(0.08‰) 0 54(4.24‰) 8(0.63‰) 0 1(0.08‰) 140(10.99‰) 28(2.20‰) 1(0.08‰) 1(0.08‰) 194(15.23‰)
Sum   44 11 4 256 32 5 11 1585 76 16 15 1841
  1. AMA advanced maternal age, ONTD Open neural tube defects; Other deformity, chromosomal or structural abnormalities other than Trisomy 21, 18, and ONTD; PPV, positive predictive value