Skip to main content

Table 2 Comparation of maternal serum markers of Trisomy 21 and 18 risk value

From: New cut-off values for screening of trisomy 21, 18 and open neural tube defects (ONTD) during the second trimester in pregnant women with advanced maternal age

Group N AFP (KU/L) AFP (MoM) Free β- hCG (μg/L)
Non-AMA 197,101 37.2(19.20 ~ 75.50) 0.98(0.54 ~ 1.87) 14.30(4.45 ~ 57.20)
AMA 12,739 37.9(19.30 ~ 77.50) 1.05(0.56 ~ 1.99) 14.30(4.27 ~ 59.75)
z   6.058 21.964 1.111
P   < 0.001 < 0.001 0.911
Group   Free β- hCG (MoM) Risk value of Trisomy 21 Risk value of Trisomy 18
Non-AMA   0.99(0.33 ~ 3.60) 1/3934(1/133 ~ 1/33336) 1/46055(1/2477 ~ 1/100000)
AMA   1.02(0.33 ~ 3.97) 1/1003(1/25 ~ 1/9648) 1/11686(1/624 ~ 1/44622)
z   6.076 98.885 124.780
P   < 0.001 < 0.001 < 0.001
  1. AMA advanced maternal age, AFP alpha-fetoprotein, free β-hCG free beta human chorionic gonadotropin, MoM multiple of the median