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Table 2 Comparation of maternal serum markers of Trisomy 21 and 18 risk value

From: New cut-off values for screening of trisomy 21, 18 and open neural tube defects (ONTD) during the second trimester in pregnant women with advanced maternal age

Group

N

AFP (KU/L)

AFP (MoM)

Free β- hCG (μg/L)

Non-AMA

197,101

37.2(19.20 ~ 75.50)

0.98(0.54 ~ 1.87)

14.30(4.45 ~ 57.20)

AMA

12,739

37.9(19.30 ~ 77.50)

1.05(0.56 ~ 1.99)

14.30(4.27 ~ 59.75)

z

 

6.058

21.964

1.111

P

 

< 0.001

< 0.001

0.911

Group

 

Free β- hCG (MoM)

Risk value of Trisomy 21

Risk value of Trisomy 18

Non-AMA

 

0.99(0.33 ~ 3.60)

1/3934(1/133 ~ 1/33336)

1/46055(1/2477 ~ 1/100000)

AMA

 

1.02(0.33 ~ 3.97)

1/1003(1/25 ~ 1/9648)

1/11686(1/624 ~ 1/44622)

z

 

6.076

98.885

124.780

P

 

< 0.001

< 0.001

< 0.001

  1. AMA advanced maternal age, AFP alpha-fetoprotein, free β-hCG free beta human chorionic gonadotropin, MoM multiple of the median