Accelerated fetal growth in early pregnancy and risk of preterm birth: a prospective cohort study

Table 4 Growth in early pregnancy and risk of preterm birth either spontaneous or medically induced. (N = 2838 births)

Growth at second trim scan	Spontaneous preterm birth (n = 1687)			Medically induced preterm birth (n = 1151)
	No. of women	Odds ratio (95% CI)		No. of women	Odds ratio (95% CI)
	No. of women	Crude	Adjusted^d	No. of women	Crude	Adjusted^d
Accelerated fetal growth^a	234	1.39 (1.21–1.61)^*	1.35 (1.15–1.58)^*	155	1.37 (1.15–1.63)^*	1.34 (1.11–1.63)^**
Appropriate fetal growth^b	1325	Ref	Ref	890	Ref	Ref
Delayed fetal growth^c	128	0.78 (0.64–0.92)^*	0.78 (0.63–0.96)^*	106	0.95 (0.77–1.16)^***	0.91 (0.72–1.15)^***

^aAccelerated fetal growth at second trimester scan was defined as BPD measurement at the 90th percentile, or more of the expected for gestational age
^bAppropriate fetal growth at second trimester scan was defined as BPD measurement between 10th - 90th percentile of the expected for gestational age
^cDelayed fetal growth at second trimester scan was defined as BPD measurement at the 10th percentile, or less of the expected for gestational age
^dAdjusted OR for maternal age older than 35 yrs., short maternal height < 155 cm, BMI ≥ 30 kg/m², non-Nordic origin, primiparity, smoking, IVF, chronic hypertension, pre-gestational diabetes mellitus and male fetal gender
^*p < 0.0001
^**p < 0.01
^***p = 0.05

ISSN: 1471-2393