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Table 4 Blood parameters in normotensive women with singleton (n = 44) and twin (n = 22) pregnancies

From: Morphofunctional cardiac changes in singleton and twin pregnancies: a longitudinal cohort study

  2nd trimester 3rd trimester PP1 PP2
Singleton pregnancies (women tested) (n = 42) (n = 42) (n = 41) (n = 41)
Twin pregnancies (women tested) (n = 18) (n = 21) (n = 22) (n = 22)
BNP, pg/mL SP 8.4 (5.2–11.3) 8.1 (2.9–13.3) 32.0 (15.1–52.6)* 8.0 (3.6–13.4)
TP 11.0 (5.9–21.4) 20.6 (10.0–29.6) * 56.9 (44.4–74.6) *† 6.1 (2.9–12.2)
NT-proBNP, pg/mL SP 27 (19–52) 28 (13–49) 110 (44–218) 30 (18–47)
TP 27 (18–48) 49 (30–113) * 180 (102–228) † 20 (14–48)
hs-TnI, pg/mL SP 0.9 (0.5–1.3) 1.2 (0.8–1.6) 1.9 (1.1–3.9) 1.3 (1.0–1.6)
TP 0.9 (0.2–1.8) 1.5 (1.0–2.2) 1.5 (1.3–4.7) † 0.9 (0.4–1.9)
PRA, ng/mL/h SP 20 (10–36) 15 (8.4–24) 3.6 (1.9–8.0) 0.9 (0.5–1.8)
TP 12 (5.6–20) 11 (5.1–19) 1.9 (0.9–5.9) † 1.3 (0.7–1.5) †
PAC, pg/mL SP 498 (368–747) 707 (441–1023) 96 (74.4–195) 116 (77.8–161)
TP 750 (439–1363) 503 (365–1435) 75 (52–104) *† 102 (58–142) †
Serum creatinine, mg/dL SP 0.47 (0.41–0.51) 0.49 (0.41–0.56) 0.55 (0.48–0.59) 0.61 (0.54–0.66)v
TP 0.49 (0.40–0.53) 0.54 (0.49–0.67) *† 0.56 (0.49–0.63) † 0.62 (0.52–0.63) †
eGFR, mL/min/1.73m2 SP 125 (109–138) 118 (99–140) 104 (92–120) 91 (81–109)
TP 120 (110–154) 103 (86–118) *† 101 (89–119) † 92 (89–110) †
  1. Data are presented as medians (25th – 75th); *, P < 0.05 vs. the value of singleton pregnancy. , P < 0.05 vs. value of the same group determined in the 2nd trimester
  2. eGFR Estimated glomerular filtration rate, hs-TnI High-sensitivity troponin I, NT-proBNP N-terminal fragment of precursor protein B-type natriuretic peptide, PAC Plasma aldosterone concentration, PRA Plasma renin activity, SP Singleton pregnancies, TP Twin pregnancies