Oxytocin use in trial of labor after cesarean and its relationship with risk of uterine rupture in women with one previous cesarean section: a meta-analysis of observational studies

Table 1 Characteristis of the included studies in this meta-analysis

Study	Year	Spontaneous labor							Induction labor							Initial oxytocin dose	Interval to dose increase	Maximum dose
Study	Year	N (oxytocin augmentation)	VBAC	Uterine rupture	Maternal age(y)	Maternal BMI	Gestational age (weeks)	Parity	N (oxytocin induction)	VBAC	Uterine rupture	Maternal age(y)	Maternal BMI	Gestational age (weeks)	Parity	Initial oxytocin dose	Interval to dose increase	Maximum dose
Fishel-Bartal [24]	2019	723 (46)	590	7	34.1	28.2	39	1.8	107 (107)	81	2 (2)	33.8	29.1	> 34	1.71	2 miU/min	20 min
Gobillot [27]	2018	553							248 (248)	145	8 (8)	31.64	25.56	39.41	1.51	2.5 miU/min	30 min	20miU
Kiwan [25]	2018	477 (218)	318	0	31.1		37.89	1.9	90 (45)	45	1	30.84		39.89	2.2
Hehir [26]	2016	2222 (235)	1611	4	32.1		> 37		849 (370)	370						5 mU/min	15 min	30 mU/min
Stenson [28]	2015	1193	749	0					208 (107)	107	9 (7)	34.23	25.42
Ashwal [29]	2014	1639 (1291)	1258	19	35.32		39.17	3	259 (186)	186	3	35.28		39.28	3	2.5 mU/min	20 min
Shatz [30]	2013	4263	3111	6	29.18				1576 (1062)	1062	9	29.13
Ouzounian [31]	2011	5026 (53)	4332	52	29.7		39.4	1.6	1806 (1199)	1199	22	30		40.4	1.6
Kwee [32]	2007	2592 (536)		27 (10)					682 (308)		4
Lin [33]	2004	2523		11					572 (430)		7 (5)
Landon [6]	2004	12,694 (6009)		76 (52)	28.7				4708 (1864)		48	28.7
Blanchette [34]	2001	292 (288)		5 (4)					174 (174)		7 (7)
Zelop [13]	1999	2214 (1072)		16 (11)					560		13 (12)					1 to 2 mU/min to 20 mU/min
Chua [35]	1989	185 (75)		0					22 (22)		0					2.5 mU/min	30 min	12.5 mU/min

ISSN: 1471-2393