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Table 2 Risk factors of medication-related problems, excluding iron preparations a

From: Medication-related problems among hospitalized pregnant women in a tertiary teaching hospital in Ethiopia: a prospective observational study

Variable category

No. (%) 1117 (100)

Non-Iron MRPs b

Crude OR (95% CI)

Adjusted OR (95% CI) c

No MRPs

≥1 MRP

Age

  ≤ 20

223 (20.0)

190

33

1

 

  21–25

388 (34.7)

325

63

1.12 [0.71, 1.76]

 

 26–30

320 (28.7)

259

61

1.36 [0.85, 2.16]

 

  ≥ 31

186 (16.7)

159

27

0.98 [0.56, 1.70]

 

Residence place

 Urban

595 (53.3)

493

102

1

 

 Rural

522 (46.7)

440

82

0.90 [0.66, 1.24]

 

Chronic disease

 No

1061 (95.0)

892

169

1

1

 Yes

56 (5.0)

41

15

1.93 [1.05, 3.57]

1.91 [1.02, 3.58]

Medicinal plant used in current pregnancy

 Yes

319 (28.6%)

265

54

1

 

 No

798 (71.4%)

668

130

0.96 [0.68, 1.35]

 

Alcohol consumers

 Yes

46 (4.1)

37

9

1

 

 No

1071 (95.9)

896

175

0.80 [0.38, 1.69]

 

Khat chewers d

 Yes

65 (5.8)

59

6

1

 

 No

1052 (94.2)

874

178

2.00 [0.85, 4.71]

 

No. of medicines during admission

  < 5 medication

631 (57.3)

520

111

1

 

  ≥ 5 medication

470 (42.7)

399

71

0.83 [0.60, 1.15]

 

No. of medicines prior to admission

 No past medication

165 (14.8)

152

13

1

1

 Only one past medication

666 (59.6)

546

120

2.57 [1.41, 4.68]

2.38 [1.24, 4.56]

 Two or more past medications

286 (25.6)

235

51

2.54 [1.34, 4.82]

2.21 [1.12, 4.38]

Duration of hospital stay

  ≤ 3 days

667 (59.7)

555

112

1

 

  > 3 days

450 (40.3)

378

72

0.94 [0.68, 1.31]

 

Gestational age

 Preterm pregnancy

231 (20.7)

199

32

1

 

 Term pregnancy

735 (65.8)

608

127

1.30 [0.85, 1.98]

 

 Post term pregnancy

62 (5.6)

51

11

1.34 [0.63, 2.84]

 

 Others

89 (8.0)

75

14

1.16 [0.59, 2.30]

 

Patient ward

 Gynaecology ward

125 (11.2)

113

12

1

1

 Maternity ward

992 (88.8)

820

172

1.98 [1.07, 3.66]

1.34 [0.68, 3.58]

Adverse pregnancy outcome in the current pregnancy

 Yes

217 (19.4)

185

32

1

 

 No or not yet delivered and outcome not yet known

900 (80.6)

748

152

1.18 [0.78, 1.78]

 

Previous adverse pregnancy outcome

 Yes

123 (11.0)

106

17

1

 

 No/not Applicable

994 (89.0)

827

167

1.26 [0.74, 2.16]

 

Parity

 Primiparous

227 (20.3)

203

24

1

1

 Nulliparous

441 (39.5)

360

81

1.90 [1.17, 3.10]

1.99 [1.22, 3.24]

 Multiparous

449 (40.2)

370

79

1.81 [1.11, 3.94]

1.91 [1.17, 3.12]

  1. Bold, statistically significant, P < 0.05
  2. Abbreviations: OR: odd ratio; CI: Confidence interval
  3. a Numbers may not add up to 100% due to missing values
  4. b No MRPs = MRPs due to other medications + Patients with No MRPs. ≥1 MRP = ≥1 MRPs due to iron sulphate
  5. c Adjusted for chronic disease, number of medicines prior to admission, patient ward and parity
  6. d Khat (Catha edulis) plant leaves are chewed by people to attain a state of euphoria and stimulation