Skip to main content

Table 3 Summary of findings among studies comparing immediate induction with delayed induction of labour

From: Immediate versus delayed induction of labour in hypertensive disorders of pregnancy: a systematic review and meta-analysis

Outcome Number of studies pooled Events
Immediate Induction of labour
Total Immediate Induction of labour Events Delayed induction Total
Delayed induction
Pooled RR (95% CI) I2 Reference Figure
Early onset severe pre-eclampsia
 Maternal mortality 3 0 630 1 636 0.34 (0.01–8.23) NA [24, 25, 31] Additional file 2: Appendix 1.1
 Eclampsia 2 1 179 1 180 0.98 (0.06–15.58) NA [31, 33] Additional file 2: Appendix 1.4
 Severe renal impairment 3 1 199 4 198 0.32 (0.05–1.99) 0% [31,32,33] Additional file 2: Appendix 1.6
 HELLP syndrome 4 7 872 18 856 0.40 (0.17–0.94) 0% [22, 23, 27, 28] Additional file 2: Appendix 1.7
 Caesarean section 6 463 710 500 718 0.95 (0.89–1.01) 10% [24, 25, 30,31,32,33] Additional file 2: Appendix 1.13
 Placental abruption 4 7 225 17 228 0.47 (0.20–1.12) 0% [25, 31,32,33] Additional file 2: Appendix 1.14
 Stillbirths 5 1 689 2 695 0.60 (0.07–4.73) 0% [24, 30,31,32,33] Additional file 2: Appendix 1.16
 Perinatal mortality 5 21 672 19 677 1.14 (0.64–2.02) 0% [24, 25, 30,31,32] Additional file 2: Appendix 1.19
 Neonatal mortality 5 10 581 6 588 1.60 (0.66–3.88) 0% [24, 25, 30,31,32] Additional file 2: Appendix 1.22
 Respiratory distress syndrome 3 81 537 56 542 1.69 (1.00–2.85) 55% [24, 32, 33] Additional file 2: Appendix 1.24
 Small for gestational age babies 4 94 669 149 677 0.49 (0.29–0.84) 60% [24, 30, 31, 33] Additional file 2: Appendix 1.29
 Neonatal intensive care unit admission 4 183 669 168 667 1.22 (0.95–1.56) 75% [24, 30, 31, 33] Additional file 2: Appendix 1.32
 Intraventricular haemorrhage 1 4 137 1 138 4.03 (0.46–35.59) NA [33]
 Necrotizing enterocolitis 3 9 203 3 205 2.23 (0.42–11.87) 29% [31,32,33] Additional file 2: Appendix 1.33
Late onset mild pre-eclampsia
 Maternal mortality 4 1 1099 0 1110 3.07 (0.13–75.19) NA [15, 22, 23, 27] Additional file 2: Appendix 1.2
 Eclampsia 4 1 1099 2 1110 0.76 (0.05–11.18) 34% [15, 22, 23, 27] Additional file 2: Appendix 1.3
 Severe renal impairment 2 5 99 14 101 0.36 (0.14–0.92) NA [22, 29] Additional file 2: Appendix 1.5
 HELLP syndrome 2 22 179 19 180 1.15 (0.65–2.02) 0% [31, 33] Additional file 2: Appendix 1.8
 Thromboembolic disease 3 2 1050 1 1059 1.60 (0.20–12.99) 0% [15, 23, 27] Additional file 2: Appendix 1.9
 Postpartum haemorrhage 3 46 740 57 751 0.82 (0.56–1.19) 0% [15, 22, 27] Additional file 2: Appendix 1.10
 Caesarean section 6 276 1243 288 1235 0.95 (0.82–1.09) 0% [15, 22, 23, 27,28,29] Additional file 2: Appendix 1.11
 Stillbirths 3 1 814 5 801 0.17 (0.02–1.45) NA [15, 23, 26] Additional file 2: Appendix 1.15
 Perinatal mortality 4 1 1099 0 1110 3.12 (0.13–74.80) NA [15, 22, 23, 27] Additional file 2: Appendix 1.18
 Neonatal mortality 4 1 1099 0 1110 3.12 (0.13–74.80) NA [15, 22, 23, 27] Additional file 2: Appendix 1.21
 Respiratory distress syndrome 3 32 771 13 740 2.15 (1.14–4.06) 0% [23, 27, 28] Additional file 2: 1.23
 Neonatal seizures 1 4 351 1 348 3.97 (0.45–35.30) NA [23] Additional file 2: Appendix 1.26
 Small for gestational age babies 4 240 841 256 834 1.19 (0.73–1.94) 45% [15, 22, 27, 28] Additional file 2: Appendix 1.27
 Neonatal intensive care unit admission 5 68 1140 49 1119 1.28 (0.87–1.87) 10% [15, 22, 23, 27, 28] Additional file 2: Appendix 1.30
Early onset mild pre-eclampsia
 Caesarean 2 152 179 113 159 1.49 (0.68–3.23) 73% [16, 26] Additional file 2: Appendix 1.12
 Perinatal mortality 2 27 334 22 329 1.20 (0.70–2.07) 0% [16, 26] Additional file 2: Appendix 1.17
 Neonatal mortality 2 23 179 16 159 1.24 (0.68–2.25) 0% [16, 26] Additional file 2: Appendix 1.20
 Neonatal seizures 1 3 141 1 121 2.57 (0.27–24.43) NA [16] Additional file 2: Appendix 1.25
 Small for gestational age babies 1 6 38 4 38 1.50 (0.46–4.89) NA [16] Additional file 2: Appendix 1.28
 Neonatal intensive care unit admission 1 12 38 3 38 4.00 (1.23–13.05) NA [16] Additional file 2: Appendix 1.31
 Intraventricular haemorrhage 1 34 141 16 121 1.82 (1.06–3.14) NA [26]
  1. NA Not applicable