From: Prenatal diagnosis of fetal microhydranencephaly: a case report and literature review
First author (year) | GW at delivery | Delivery Method | Sex | Fetal birth weight (g) | OFC at birth (SD) | Overlapping suture | Prominent occipital bone | Sloping forehead | Scalp rugae | Normal scalp hair | Cerebral abnormality | Hydrocephalus | GW at prenatal diagnosis | Fetal findings at prenatal diagnosis | Imaging modalities used for prenatal diagnosis | Chromosomal abnormality | Prognosis |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Russell (1984) [1] | 37 | NS | F | 2400 | -6.4 | + | + | + | + | + | Severe atrophy | + | 36 | Microcephalus | US | Not tested | Death at 4 months |
Term | NS | F | 1786 | -7.5 | + | + | + | + | + | Cerebrum defect | + | NA | Microcephalus | US | Not tested | Alive at 4 months | |
Term | NS | M | 1960 | -6.6 | + | + | NS | + | + | Atrophy and calcification | + | 34 | Microcephalus | US | Normal karyotype | Death at 23 days | |
Bönnemann (1990) [7] | 35 | VD | F | 1670 | -6.0 | + | + | - | + | + | Atrophy | + | NA | Microcephalus | US | NS | NS |
Alexander (1995) [2] | Term | VD | F | 4200 | -0.6 | NS | NS | - | + | + | Severe atrophy | + | 37 | Microcephalus | US | Normal karyotype | Alive at 2.5 years |
Gabis (1997) [19] | 38 | CS | M | NS | -0.9 | + | NS | + | NS | + | Porencephaly | - | 30 | Microcephalus, intracranial hemorrhage, porencephalic cyst | US | NS | NS |
DeJonge (1997) [20] | 34 | NS | F | 2014 | NS | + | + | + | + | + | Cerebrum defect | NS | 28 | Microcephalus | US | Normal karyotype | Death at 1 day |
Villó (2001) [23] | 38 | VD | F | 2055 | -5.0 | + | + | NS | + | + | Severe atrophy | + | 25 | Microcephalus | US | Normal karyotype | Alive at 3 years |
Schram (2004) [3] | 38 | NS | M | 2880 | -2.8 | + | + | + | + | + | Severe hypoplasia | + | 28 | Occipital flattening | US | Normal karyotype | Death at 2 years |
36 | VD | M | 2590 | -3.4 | + | NS | - | + | + | Aplasia and atrophy | + | 36 | Microcephalus, small brain | US | Normal karyotype | Death at 1 month | |
33 | VD | F | 2050 | -1.0 | + | NS | - | + | + | Atrophy and calcification | + | 26 | Microcephalus, small brain, hypoplastic cerebellum, normal brain stem, hydrocephalus,excess amount of cerebrospinal fluid | US, MRI | Normal karyotype | Death at 1 day | |
Behunova (2010) [24] | 40 | NS | M | 3770 | -2.5 | NS | NS | + | + | + | Severe atrophy | + | 28–31 | Microcephalus | US | Normal karyotype | Alive at 5.5 years |
Abdel-Salam (2015) [6] | Term | CS | M | 3000 | -3.0 | + | + | NS | NS | NS | Severe hypoplasia | + | 28 | Microcephalus, hypoplastic cerebrum, hypoplastic cerebellum, hypoplastic brain stem, hydrocephalus | US, MRI | NS | Death at several days |
28 | VD | F | NS | NS | + | + | + | NS | NS | Severe hypoplasia | + | 24 | Microcephalus, hypoplastic cerebrum, hypoplastic cerebellum, hypoplastic brain stem, hydrocephalus, prominent occipital bone | US, MRI | Normal karyotype | Termination | |
Omoto (present case) | 37 | VD | M | 2342 | -5.4 | - | + | + | - | Partial defect | Cerebrum defect | + | 23 | Microcephalus, cerebrum defect, cerebellum hypoplasia, normal brain stem, hydrocephalus, excess amount of cerebrospinal fluid, prominent occipital bone, sloping forehead | US, MRI, CT | 46, XY, inv(9)(p12q13) | Alive at 18 months |