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Table 3 Costs, number of patient visits and test turnaround time of different screening strategies

From: Prenatal screening for trisomy 21: a comparative performance and cost analysis of different screening strategies

Strategy Contingent cfDNA screening Reflex cfDNA screening Primary cfDNA screening
Risk cut-off(s) of eFTS 1 in 1000 1 in 1000 1 in 1000 1 in 50 and 1 in 1000
cfDNA screening technology Sequencing Sequencing RCA/Imaging solution RCA/Imaging solution Sequencing RCA/Imaging solution
Costs (CAD)
 Total program $20,053,297 $18,759,518 $18,132,468 $20,059,786 $43,165,976 $41,743,817
 Per woman screening $201 $188 $181 $201 $432 $417
 Per case of T21 diagnosed prenatally $82,005 $76,529 $74,112 $81,169 $161,305 $159,510
 Per case of T21 diagnosed prenatally (all cfDNA screening no-call have a PND) $81,998 $76,691 $74,149 $81,455 $167,680 $162,167
 Per additional case of T21 diagnosed compared to the contingent cfDNA screening $3799 $1,795,639 $1,687,537
Number of patient visit and turnaround time
 Number of visit (1st cfDNA screening has result) 3 1 1 1 1 1
 Number of visit (1st cfDNA screening no-call result) 4 1 1 1 2 1
 Days from initial sample received to cfDNA screening result (1st cfDNA screening has result) 16 13 7 7 10 4
 Days from initial sample received to cfDNA screening result (1st cfDNA screening no-call result) 26 13 7 7 20 4
  1. cfDNA screening cell free fetal DNA screening, eFTS Enhanced first trimester screening, RCA/Imaging solution automated high precision rolling circle amplification /Imaging solution, T21 Trisomy 21, PND Prenatal diagnosis testing