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Table 5 Impact of preeclampsia on longitudinal changes in blood pressure and metabolic indices

From: Longitudinal change in arterial stiffness after delivery in women with preeclampsia and normotension: a prospective cohort study

Outcome Covariates β estimate ± SE 95% C.I P-value
Systolic BP (mmHg) Time since delivery:
 Day 1  
 6 months −10.6 ± 2.12 −14.8, −6.41 < 0.0001
 12 months −10.3 ± 2.36 −15.0, −5.60 < 0.0001
Group:
 Control  
 Preeclampsia 21.6 ± 2.90 15.9, 27.4 < 0.0001
 Age 0.46 ± 0.41 − 0.36, 1.28 0.273
  R2(m) = 0.0502, R2(C) = 0.4083
Diastolic BP (mmHg) Time since delivery:
 Day 1  
 6 months −2.75 ± 1.46 − 5.66, 0.16 0.064
 12 months − 0.59 ± 1.63 −3.84, 2.66 0.720
Group:
 Control  
 Preeclampsia 16.1 ± 2.07 12.0, 20.2 < 0.0001
 Age 0.32 ± 0.29 − 0.27, 0.90 0.287
  R2(m) = 0.0343, R2(C) = 0.4393   
Waist/Hip ratio Time since delivery:
 Day 1  
 6 months − 0.10 ± 0.02 − 0.14, − 0.06 < 0.0001
 12 months − 0.07 ± 0.02 − 0.11, − 0.04 0.0001
Group:
 Control  
 Preeclampsia 0.04 ± 0.02 0.01, 0.07 0.016
 Age 0.006 ± 0.002 − 0.011, − 0.001 0.012
  R2(m) = 0.0252, R2(C) = 0.0498   
Total cholesterol (mg/dL) Time since delivery:
 Day 1  
 6 months −36.7 ± 5.69 − 48.1, −25.4 < 0.0001
 12 months − 45.9 ± 6.36 −58.5, − 33.2 < 0.0001
Group:
 Control  
 Preeclampsia 20.5 ± 9.23 2.08, 38.8 0.030
 Age − 0.14 ± 1.30 −2.73, 2.44 0.913
  R2(m) = 0.1370, R2(C) = 0.5486
LDL cholesterol (mg/dL) Time since delivery:
 Day 1  
 6 months −14.3 ± 4.59 −23.4, −5.14 0.003
 12 months −20.7 ± 5.15 −31.0, − 10.5 0.0001
Group:
 Control  
 Preeclampsia 51.5 ± 30.8 − 9.82, 112.9 0.099
 Age − 4.50 ± 4.31 −13.1, 4.09 0.30
  R2(m) = 0.4839, R2(C) = 0.9700   
TG (mg/dL) Time since delivery:
 Day 1  
 6 months − 119.5 ± 12.5 − 144.3, − 94.7 < 0.0001
 12 months −127.9 ± 13.8 − 155.5, − 100.3 < 0.0001
Group:
 Control  
 Preeclampsia 31.7 ± 15.7 0.41, 62.9 0.047
 Age − 0.41 ± 2.28 − 4.96, 4.13 0.857
  R2(m) = 0.0288, R2(C) = 0.3366   
HDL cholesterol (mg/dL) Time since delivery:
 Day 1  
 6 months − 5.15 ± 1.78 − 8.68, −1.61 0.005
 12 months − 5.17 ± 1.98 − 9.12, − 1.23 0.011
Group:
 Control  
 Preeclampsia −1.80 ± 2.73 −7.25, 3.64 0.511
Age − 0.23 ± 0.39 −1.01, 0.55 0.558
  R2(m) = 0.0878, R2(C) = 0.5112   
Creatinine (mg/dL) Time since delivery:
 Day 1  
 6 months − 0.002 ± 0.022 − 0.046, 0.041 0.913
 12 months 0.025 ± 0.024  − 0.024, 0.073 0.310
Group:    
 Control  
 reeclampsia 0.115 ± 0.041 0.032, 0.197 0.007
Age − 0.01 ± 0.006 − 0.021, 0.002 0.089
  R2(m) = 0.0702, R2(C) = 0.6368   
AST (IU/L) Time since delivery:
 Day 1  
 6 months − 6.07 ± 2.11 − 10.3, −1.88 0.005
 12 months − 6.49 ± 2.31 − 11.1, − 1.89 0.006
Group:
 Control  
 Preeclampsia 4.78 ± 1.78 1.22, 8.35 0.009
 Age − 0.15 ± 0.27 − 0.69, 0.39 0.576
  R2(m) = Not Available a, R2(C) = Not Availablea  
ALT (IU/L) Time since delivery:
 Day 1  
 6 months − 3.00 ± 2.97 − 9.91, 2.90 0.315
 12 months − 6.55 ± 3.27 −13.1, − 0.045 0.049
Group:
 Control  
 Preeclampsia 7.23 ± 2.86 1.53, 12.9 0.014
 Age 0.016 ± 0.43 − 0.83, 0.86 0.97
 R2(m) = 0.0087, R2(C) = 0.0652   
  1. aThere is a case where a variance component is zero or very near zeros in mixed models, and thus R2 cannot be calculated
  2. R2(m) marginal R2, R2(C) conditional R2, SE Standard error, C. I Confidence interval, BP Blood pressure, LDL Low-density lipoprotein, TG Triglyceride, HDL High-density lipoprotein, AST Aspartate transaminase, ALT Alanine aminotransferase