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Table 5 Impact of preeclampsia on longitudinal changes in blood pressure and metabolic indices

From: Longitudinal change in arterial stiffness after delivery in women with preeclampsia and normotension: a prospective cohort study

Outcome

Covariates

β estimate ± SE

95% C.I

P-value

Systolic BP (mmHg)

Time since delivery:

 Day 1

–

–

 

 6 months

−10.6 ± 2.12

−14.8, −6.41

< 0.0001

 12 months

−10.3 ± 2.36

−15.0, −5.60

< 0.0001

Group:

 Control

–

–

 

 Preeclampsia

21.6 ± 2.90

15.9, 27.4

< 0.0001

 Age

0.46 ± 0.41

− 0.36, 1.28

0.273

 

R2(m) = 0.0502, R2(C) = 0.4083

Diastolic BP (mmHg)

Time since delivery:

 Day 1

–

–

 

 6 months

−2.75 ± 1.46

− 5.66, 0.16

0.064

 12 months

− 0.59 ± 1.63

−3.84, 2.66

0.720

Group:

 Control

–

–

 

 Preeclampsia

16.1 ± 2.07

12.0, 20.2

< 0.0001

 Age

0.32 ± 0.29

− 0.27, 0.90

0.287

 

R2(m) = 0.0343, R2(C) = 0.4393

  

Waist/Hip ratio

Time since delivery:

 Day 1

–

–

 

 6 months

− 0.10 ± 0.02

− 0.14, − 0.06

< 0.0001

 12 months

− 0.07 ± 0.02

− 0.11, − 0.04

0.0001

Group:

 Control

–

–

 

 Preeclampsia

0.04 ± 0.02

0.01, 0.07

0.016

 Age

0.006 ± 0.002

− 0.011, − 0.001

0.012

 

R2(m) = 0.0252, R2(C) = 0.0498

  

Total cholesterol (mg/dL)

Time since delivery:

 Day 1

–

–

 

 6 months

−36.7 ± 5.69

− 48.1, −25.4

< 0.0001

 12 months

− 45.9 ± 6.36

−58.5, − 33.2

< 0.0001

Group:

 Control

–

–

 

 Preeclampsia

20.5 ± 9.23

2.08, 38.8

0.030

 Age

− 0.14 ± 1.30

−2.73, 2.44

0.913

 

R2(m) = 0.1370, R2(C) = 0.5486

LDL cholesterol (mg/dL)

Time since delivery:

 Day 1

–

–

 

 6 months

−14.3 ± 4.59

−23.4, −5.14

0.003

 12 months

−20.7 ± 5.15

−31.0, − 10.5

0.0001

Group:

 Control

–

–

 

 Preeclampsia

51.5 ± 30.8

− 9.82, 112.9

0.099

 Age

− 4.50 ± 4.31

−13.1, 4.09

0.30

 

R2(m) = 0.4839, R2(C) = 0.9700

  

TG (mg/dL)

Time since delivery:

 Day 1

–

–

 

 6 months

− 119.5 ± 12.5

− 144.3, − 94.7

< 0.0001

 12 months

−127.9 ± 13.8

− 155.5, − 100.3

< 0.0001

Group:

 Control

–

–

 

 Preeclampsia

31.7 ± 15.7

0.41, 62.9

0.047

 Age

− 0.41 ± 2.28

− 4.96, 4.13

0.857

 

R2(m) = 0.0288, R2(C) = 0.3366

  

HDL cholesterol (mg/dL)

Time since delivery:

 Day 1

–

–

 

 6 months

− 5.15 ± 1.78

− 8.68, −1.61

0.005

 12 months

− 5.17 ± 1.98

− 9.12, − 1.23

0.011

Group:

 Control

–

–

 

 Preeclampsia

−1.80 ± 2.73

−7.25, 3.64

0.511

Age

− 0.23 ± 0.39

−1.01, 0.55

0.558

 

R2(m) = 0.0878, R2(C) = 0.5112

  

Creatinine (mg/dL)

Time since delivery:

 Day 1

–

–

 

 6 months

− 0.002 ± 0.022

− 0.046, 0.041

0.913

 12 months

0.025 ± 0.024

 − 0.024, 0.073

0.310

Group:

   

 Control

–

–

 

 reeclampsia

0.115 ± 0.041

0.032, 0.197

0.007

Age

− 0.01 ± 0.006

− 0.021, 0.002

0.089

 

R2(m) = 0.0702, R2(C) = 0.6368

  

AST (IU/L)

Time since delivery:

 Day 1

–

–

 

 6 months

− 6.07 ± 2.11

− 10.3, −1.88

0.005

 12 months

− 6.49 ± 2.31

− 11.1, − 1.89

0.006

Group:

 Control

–

–

 

 Preeclampsia

4.78 ± 1.78

1.22, 8.35

0.009

 Age

− 0.15 ± 0.27

− 0.69, 0.39

0.576

 

R2(m) = Not Available a, R2(C) = Not Availablea

 

ALT (IU/L)

Time since delivery:

 Day 1

–

–

 

 6 months

− 3.00 ± 2.97

− 9.91, 2.90

0.315

 12 months

− 6.55 ± 3.27

−13.1, − 0.045

0.049

Group:

 Control

–

–

 

 Preeclampsia

7.23 ± 2.86

1.53, 12.9

0.014

 Age

0.016 ± 0.43

− 0.83, 0.86

0.97

 

 R2(m) = 0.0087, R2(C) = 0.0652

  
  1. aThere is a case where a variance component is zero or very near zeros in mixed models, and thus R2 cannot be calculated
  2. R2(m) marginal R2, R2(C) conditional R2, SE Standard error, C. I Confidence interval, BP Blood pressure, LDL Low-density lipoprotein, TG Triglyceride, HDL High-density lipoprotein, AST Aspartate transaminase, ALT Alanine aminotransferase
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ISSN: 1471-2393

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