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Table 3 The neonatal outcomes of patients among groups A–E stratified by 35 years of age

From: Live birth rate and neonatal outcomes of different quantities and qualities of frozen transferred blastocyst in patients requiring whole embryo freezing stratified by age

  <35 years of age ≥ 35 years of age
Group A Group B Group C Group D Group E P Group A Group B Group C Group D Group E P
Cycles (n) 1425 844 206 183 120   144 269 107 39 25  
Preterm birth
(<37weeks)
11.77a,b,c
(91/773)
39.45
(215/545)
33.33
(44/132)
42.70
(38/89)
4.55d
(2/44)
0.000 8.20a,b
(5/61)
35.0
(56/160)
25.0
(13/52)
16.67
(2/12)
16.67
(1/6)
0.001
Singleton 8.67a
(67/773)
3.30
(18/545)
6.82
(9/132)
3.37
(3/89)
4.55
(2/44)
0.001 4.92
(3/61)
5.62
(9/160)
7.69
(4/52)
0.0
(0/12)
0.0
(0/6)
0.755
Twin 3.10a,b,c
(24/773)
36.15
(197/545)
26.51
(35/132)
39.33
(35/89)
0.0d
(0/44)
0.000 3.28a,b
(2/61)
29.38
(47/160)
17.31
(9/52)
16.67
(2/12)
16.67
(1/6)
0.000
Gestational age (weeks) 38.70 ± 1.94a,b,c 37.37 ± 2.52 37.59 ± 2.52 36.86 ± 3.33 39.18 ± 1.91d 0.000 38.72 ± 1.23a,b,c 37.61 ± 2.33 37.66 ± 2.89 37.00 ± 3.43 38.32 ± 0.86d 0.022
Singleton 38.80 ± 1.83 38.94 ± 1.71 38.51 ± 2.18 39.00 ± 1.58 39.18 ± 1.91 0.325 38.81 ± 1.56 38.59 ± 2.14 38.76 ± 1.97 38.52 ± 1.71 38.32 ± 0.86 0.951
Twin 35.32 ± 1.47 36.04 ± 2.32 36.02 ± 2.37 35.15 ± 3.01 / 0.095# 36.20 ± 0.40 35.98 ± 1.63 35.06 ± 3.21 34.29 ± 4.99 / 0.330#
Birth height (mm) 49.51 ± 2.3a,b,c 47.72 ± 3.21 48.23 ± 2.41 46.61 ± 4.26 49.89 ± 2.22d 0.000 49.77 ± 1.85a,b,c 48.03 ± 2.70 47.95 ± 3.75 48.31 ± 5.70 49.75 ± 0.96d 0.000
Singleton 49.68 ± 2.27 49.82 ± 1.98 49.88 ± 1.73 49.53 ± 1.44 49.88 ± 2.22 0.838 49.93 ± 1.76 49.50 ± 2.39 49.77 ± 2.41 50.00 ± 2.00 49.75 ± 0.96 0.868
Twin 46.66 ± 2.40 46.72 ± 2.95 46.97 ± 2.20 45.50 ± 4.32 / 0.113# 46.75 ± 0.35 46.90 ± 1.91 45.70 ± 3.70 45.83 ± 6.83 / 0.155#
Birth weight (kg) 3.16 ± .054a,b,c 2.73 ± 0.61 2.79 ± 0.62 2.57 ± 0.66 3.19 ± 0.43d 0.000 3.12 ± 0.51a,b,c 2.76 ± 0.60 2.81 ± 0.75 2.55 ± 0.88 3.30 ± 0.29d 0.000
Singleton 3.22 ± 0.50 3.27 ± 0.51 3.24 ± 0.52 3.17 ± 0.33 3.19 ± 0.43 0.583 3.36 ± 0.49 3.22 ± 0.50 3.24 ± 0.49 3.26 ± 0.45 3.30 ± 0.29 0.666
Twin 2.34 ± 0.43 2.48 ± 0.45 2.44 ± 0.42 2.31 ± 0.54 / 0.113# 2.55 ± 0.25 2.43 ± 0.34 2.24 ± 0.52 2.00 ± 0.82 / 0.142#
Still birth 0.0
(0/773)
0.0
(0/545)
0.0
(0/132)
0.0
(0/89)
0.0
(0/44)
/ 0.0
(0/61)
0.0
(0/160)
0.0
(0/52)
0.0
(0/12)
0.0
(0/6)
/
Congenital anomalies 1.64
(13/795)
1.60
(13/811)
1.09
(2/184)
1.52
(2/132)
2.27
(1/44)
0.958 0.0
(0/63)
0.0
(0/217)
0.0
(0/68)
0.0
(0/15)
0.0
(0/6)
/
Sex ratio(male/female) 1.30
(450/345)
1.43
(477/334)
1.10
(97/87)
1.46
(78/54)
0.83
(20/24)
0.445 1.43
(37/26)
1.22
(119/98)
1.16
(37/31)
0.63
(6/9)
1.00
(3/3)
0.632
Low birth weight
(<2500 g) in singleton
7.04a,b,c
(56/795)
27.25
(221/811)
28.26
(52/184)
34.09
(45/132)
4.55d
(2/44)
0.000 6.34a,b
(4/63)
29.03
(63/217)
27.94
(19/68)
13.33
(2/15)
0.0
(0/6)
0.002
Singleton 4.02
(32/795)
4.44
(36/811)
4.35
(8/184)
4.55
(6/132)
4.55
(2/44)
0.977 3.17
(2/63)
2.76
(6/217)
1.47
(1/68)
0.0
(0/1)
0.0
(0/6)
0.833
Twin 3.02a,b,c
(24/795)
22.81
(185/811)
23.91
(44/184)
29.54
(39/132)
0.0d
(0/44)
0.000 3.17a,b
(2/63)
26.27
(57/217)
26.47
(18/68)
13.33
(2/15)
0.0
(0/6)
0.001
Very low birth weight (<1500 g) in singleton 0.75a,c
(6/795)
2.84
(23/811)
1.63
(3/184)
5.30
(7/132)
0.0
(0/44)
0.001 0.0c
(0/63)
2.76
(6/217)
2.94
(2/68)
13.33
(2/15)
0.0
(0/6)
0.045
Singleton 0.63
(5/795)
0.12
(1/811)
0.54
(1/184)
0.0
(0/132)
0.0
(0/44)
0.324 0.0
(0/63)
0.5
(1/217)
0.0
(0/68)
0.0
(0/15)
0.0
(0/6)
0.879
Twin 0.12a,c
(1/795)
2.72
(22/811)
1.09
(2/184)
5.30
(7/13)
0.0
(0/44)
0.000 0.0c
(0/63)
2.30
(5/217)
2.94
(2/68)
13.33
(2/15)
0.0
(0/6)
0.029
  1. #comparison among groups A–D. P < .05 was considered statistically significant
  2. aP < .05 compared to group B
  3. bP < .05 compared to group C
  4. cP < .05 compared to group D
  5. dP < .05 between groups D and E