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Table 4 Pharmacotherapy use and maternal and infant outcomes for the pre-and-post intervention groups

From: An implementation science approach for developing and implementing a dietitian-led model of care for gestational diabetes: a pre-post study

Maternal and infant outcomes Pre-Intervention
(n = 125)
Post-Intervention
(n = 120)
Unadjusted
P-Value
Adjusted
P-Value*
OR (CI)**
Binary outcomes
Requiring any pharmacotherapy, n (%) 46 (37%) 56 (47%) 0.10 0.15 1.53 (0.86–2.81)
 Metformin 20 (16%) 10 (8.3%)    
 Insulin 14 (11%) 33 (28%)    
 Metformin + insulin 12 (10%) 14 (12%)    
Large-for-gestational age, n (%) 10 (8.0%) 12 (10.1%) 0.57 0.56 1.30 (0.54–3.15)
Small-for-gestational age, n (%) 10 (8.0%) 12 (10.1%) 0.57 0.81 1.12 (0.45–2.79)
Continuous outcomes
 Gestational age for pharmacotherapy, mean (SD), weeks 30.1 (4.7) 27.8 (6.8) 0.05   
 Infant birthweight, mean (SD), grams 3352 (499) 3290 (470) 0.32   
  1. *Confounders in logistic regression modelling: Requiring any pharmacotherapy (maternal age > 30 years, pre-pregnancy BMI > 30 kg/m2, previous GDM, diagnostic fasting > 5.2, early diagnosis < 24 weeks gestation, family history of type 2 diabetes mellitus); large-for-gestational age (pre-pregnancy BMI > 30 kg/m2); small -for-gestational age (smoking, during pregnancy)
  2. ** OR, 95% confidence intervals from logistic regression models using the pre-intervention as the reference group