Table 1 Characteristics of the included studies
Author, Year | Study Design | Country | HELLP was defined | AKI (ARF) was defined | Sample size of patients with AKI in patients with HELLPa | Sample size of patients with AKI in patients without HELLP a | Major clinical outcomes | Quality score |
|---|---|---|---|---|---|---|---|---|
Gul 2004 [7] | RC | Turkey | The criteria of Sibai | creatinine level ≥ 1.2 mg/dL and/or oliguria < 400 mL/24 h | 132 (20/112) | 156 (10/146) | Kidney outcome、 | 6 |
Zuberi 1998 [14] | RC | Pakistan | The criteria of Sibai | Not clear | 38 (4/34) | 38 (1/37) | Kidney outcome、Fetal outcome、 | 5 |
Yildirim 2011 [15] | RC | Turkey | Not clear | a creatinine clearance ≤ 20 mL/min was present with an elevated serum creatinine level ≥ 2 mg/dL | 196 21/175 | 903 14/889 | Kidney outcome、Fetal outcome | 6 |
F. Abroug 1992 [16] | PC | Tunisia | hemolysis, increased liver enzymes and thrombocytopenia. | diagnosed on an increased creatinine level over 160 umol/1 | 12 (8/4) | 50 (15/35) | Kidney outcome, Fetal outcome | 6 |
Haddad 2000 [5] | RC | USA | The criteria of Sibai | oligouria or anuria in association with creatinine clearance ≤ 20 mL/min and an elevated serum creatinine level ≥ 2 mg/dL | 30 (1/29) | 30 (0/30) | Kidney outcome | 6 |
Liu 2006 [17] | RC | China taiwan | Hemolysis, elevated liver enzymes, low platelet count | severe reduction in renal function with elevated serum creatinine greater than 120 μmol/L (> 1.4 mg/dL). | 52 (14/38) | 212 (7/205) | Kidney outcome | 7 |
Martin 1993 [18] | RC | USA | the presence of thrombocytopenia, hepatic dysfunction, and haemolysis | Not clear | 62 (2/60) | 55 (0/55) | Kidney outcome | 6 |
Turgut 2010 [19] | RC | Turkey | the presence of thrombocytopenia, hepatic dysfunction, and haemolysis | creatinine clearance of ≤ 20 mL/min and an elevated serum creatinine level of ≥ 2 mg/dL | 111 (9/102) | 467 (11/456) | Kidney outcome | 6 |