Table 1 Study characteristics and risk of bias assessment
From: Iron stores in pregnant women with sickle cell disease: a systematic review
Author (year), country | Objective studied | Mean Age | Mean Gestational age | Study design | Recent Transfusion (< 6 months) | Hemoglobin genotype (number of participants) | Sample size | Diagnostic method | Diagnostic criteria | Participants with IDA | Prevalence | Bias |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Akinyanju et al. (1987), Nigeria [13] | 1,3 | 22.8 | NA | Randomized control trial | None | SS (11) SC (3) | 14 | Bone marrow iron stain | Grade 0–1/5 | 3 | 21.43 ± 4.49 | Selection bias: unclear Reporting bias: unclear Performance bias: unclear Detection bias: unclear Attrition bias: Low |
Anderson et al. (1972), Jamaica [22] | 1 | 25.27 | 16.93 | Cross sectional study | Nonea | SS (7) SC (6) S-thalassemia (2) | 15 | Bone marrow iron stain Serum iron TIBCb | Grade 0–1/3 < 50 ng/dl < 240 μg/dl | 10 1 1 | 66.67 ± 15.94 6.67 ± 0.87 6.67 ± 0.87 | Fair |
Oluboyede et al. (1980), Nigeria [14] | 1 | NA | 23.3 | Case control study | None | SS (10) SC (12) | 22 | Bone marrow iron stain | Grade 0–1/3 | 14 | 63.34 ± 12.78 | Fair |
Roopnarinegnh (1976), Spain [23] | 1 | NA | 28.67 | Cross sectional study | None | SS (5) SF (1) | 6 | Bone marrow iron stain | Negative & weakly positive | 5 | 83.33 ± 25.04 | Fair |
Aken’ova et al. (1977), Nigeria [24] | 1 | NA | NA | Cross sectional study | NA | SS | 10 | Serum ferritin Serum iron | < 150 ng/dl < 50 ng/dl | 3 3 | 30 ± 8.52 30 ± 8.52 | Fair |