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Table 1 Study characteristics and risk of bias assessment

From: Iron stores in pregnant women with sickle cell disease: a systematic review

Author (year), country Objective studied Mean Age Mean Gestational age Study design Recent Transfusion (< 6 months) Hemoglobin genotype (number of participants) Sample size Diagnostic method Diagnostic criteria Participants with IDA Prevalence Bias
Akinyanju et al. (1987), Nigeria [13] 1,3 22.8 NA Randomized control trial None SS (11)
SC (3)
14 Bone marrow iron stain Grade
0–1/5
3 21.43 ± 4.49 Selection bias: unclear
Reporting bias: unclear
Performance bias: unclear
Detection bias: unclear
Attrition bias: Low
Anderson et al. (1972), Jamaica [22] 1 25.27 16.93 Cross sectional study Nonea SS (7)
SC (6)
S-thalassemia (2)
15 Bone marrow iron stain
Serum iron
TIBCb
Grade
0–1/3
< 50 ng/dl
< 240 μg/dl
10
1
1
66.67 ± 15.94
6.67 ± 0.87
6.67 ± 0.87
Fair
Oluboyede et al. (1980), Nigeria [14] 1 NA 23.3 Case control study None SS (10)
SC (12)
22 Bone marrow iron stain Grade
0–1/3
14 63.34 ± 12.78 Fair
Roopnarinegnh (1976), Spain [23] 1 NA 28.67 Cross sectional study None SS (5)
SF (1)
6 Bone marrow iron stain Negative &
weakly positive
5 83.33 ± 25.04 Fair
Aken’ova et al. (1977), Nigeria [24] 1 NA NA Cross sectional study NA SS 10 Serum ferritin
Serum iron
< 150 ng/dl
< 50 ng/dl
3
3
30 ± 8.52
30 ± 8.52
Fair
  1. aThree patients had been transfused at least once; 5 years, 3 years and 6 months prior to the pregnancy, bTotal iron binding capacity, NA: not provided in study, IDA; iron deficiency anaemia, SS; Haemoglobin SS, SC; Haemoglobin SC, SF; Haemoglobin SF, Prevalence is reported with ± confidence intervals