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Table 2 Comparison of changes in variables within and between groups after the interventiona

From: Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial

Group

Variable

1000 IU/d group

n = 37

2000 IU/d group

n = 36

p value2

before

after

changes

before

after

changes

Time

Group

Time × groupb

25(OH)D3 (nmol/ liter)

45.32 ± 29.70

71.19 ± 23.65*

24.01 ± 21.7

47.03 ± 31.70

91.82 ± 28.81*

46.7 ± 30.6

**

< 0.001

0.06

0.004

FBS (mg/dl)

74.70 ± 7.51

75.59 ± 6.98

0.89 ± 11.06

78.41

77.55

−0.86 ± 10.91

0.99

0.054

0.49

Insulin (mU/L)

7.97 ± 4.85

8.82 ± 5.47

0.85 ± 6.15

7.95 ± 5.96

10.40 ± 9.31

2.44 ± 10.28

0.11

0.53

0.44

HOMA_IR

1.45 ± 0.85

1.52 ± 1.21

0.21 ± 1.23

1.66 ± 1.11

2.03 ± 1.84

0.50 ± 2.03

0.08

0.37

0.47

TG (mg/dl)

98.59 ± 34.10

245.43 ± 68.75*

146.83 ± 59.16

97.22 ± 49.94

228.41 ± 75.03*

131.19 ± 58.16

< 0.001

0.44

0.26

TC (mg/dl)

153.78 ± 29.05

229.83 ± 48.84*

76.05 ± 38.110

158.22 ± 36.58

228.44 ± 32.13*

70.22 ± 35

< 0.001

0.49

0.84

HDL (mg/dl)

52.08 ± 8.68

62.08 ± 10.61*

10 ± 8.37

54.69 ± 12.86

64.22 ± 15.78*

9.52 ± 11.39

< 0.001

0.36

0.84

LDL (mg/dl)

81.98 ± 20.93

118.67 ± 37.38*

36.68 ± 29.93

84.08 ± 26.06

118.53 ± 23.89*

34.45 ± 27.39

< 0.001

0.86

0.74

LDL/HDL-C

1.58 ± 0.36

1.90 ± 0.44*

0.31 ± 0.44

1.56 ± 0.45

1.91 ± 0.46*

0.35 ± 0.47

< 0.001

0.92

0.76

TC/HDL-C

2.97 ± 0.44

3.71 ± 0.49*

0.73 ± 0.51

2.93 ± 0.55

3.67 ± 0.63*

0.73 ± 0.52

< 0.001

0.68

0.99

Calcium (mg/dl)

9.47 ± 0.38

8.97 ± 0.37*

−0.5 ± 0.41

9.45 ± 0.39

9.01 ± 0.32*

−0.43 ± 0.45

< 0.001

0.88

0.51

Phosphate (mg/dl)

4.37 ± 0.45

4.63 ± 1.0

0.26 ± 1.06

4.45 ± 0.62

4.45 ± 0.49

0.0 ± 0.69

0.21

0.67

0.21

iPTH (pg/ml)

17.96 ± 10.60

13.78 ± 7.05*

−4.18 ± 7.5

23.51 ± 15.77

15.15 ± 7.68*

−8.36 ± 14.17

< 0.001

0.11

0.13

MDA (nmol/mL)

21.17 ± 8.13

17.6 ± 8.7

−1.64 ± 10.42

18.87 ± 8.37

18.17 ± 8.07

1.9 ± 8.36

0.52

0.46

0.26

TAC (g/dL BSA equivalent)

2.99 ± 0.37

2.79 ± 0.58

−0.19 ± 0.67

2.84 ± 0.55

2.78 ± 0.45

−0.06 ± 0.62

0.18

0.51

0.50

  1. aAll values are expressed as means±SD (standard deviation)
  2. 2Resulted from 1-factor repeated measures ANOVA
  3. *different from baseline, p < 0.05
  4. **difference of changes between groups, P-interaction< 0.05
  5. bTime×Group: Time means from the first to the last visit of intervention and group means comparison between the two groups of intervention
  6. 25(OH)D3 25-hydroxyvitamin D3, FBS fasting serum glucose, TC total cholesterol, TG triglycerides, LDL low-density lipoprotein, HDL high-density lipoprotein, iPTH intact parathyroid hormone, MDA malondialdehyde, TAC total antioxidant capacity, HOMA-IR homeostasis model assessment of insulin resistance
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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