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Table 2 Comparison of changes in variables within and between groups after the interventiona

From: Evaluation of the efficacy of two doses of vitamin D supplementation on glycemic, lipidemic and oxidative stress biomarkers during pregnancy: a randomized clinical trial

Group
Variable
1000 IU/d group
n = 37
2000 IU/d group
n = 36
p value2
before after changes before after changes Time Group Time × groupb
25(OH)D3 (nmol/ liter) 45.32 ± 29.70 71.19 ± 23.65* 24.01 ± 21.7 47.03 ± 31.70 91.82 ± 28.81* 46.7 ± 30.6
**
< 0.001 0.06 0.004
FBS (mg/dl) 74.70 ± 7.51 75.59 ± 6.98 0.89 ± 11.06 78.41 77.55 −0.86 ± 10.91 0.99 0.054 0.49
Insulin (mU/L) 7.97 ± 4.85 8.82 ± 5.47 0.85 ± 6.15 7.95 ± 5.96 10.40 ± 9.31 2.44 ± 10.28 0.11 0.53 0.44
HOMA_IR 1.45 ± 0.85 1.52 ± 1.21 0.21 ± 1.23 1.66 ± 1.11 2.03 ± 1.84 0.50 ± 2.03 0.08 0.37 0.47
TG (mg/dl) 98.59 ± 34.10 245.43 ± 68.75* 146.83 ± 59.16 97.22 ± 49.94 228.41 ± 75.03* 131.19 ± 58.16 < 0.001 0.44 0.26
TC (mg/dl) 153.78 ± 29.05 229.83 ± 48.84* 76.05 ± 38.110 158.22 ± 36.58 228.44 ± 32.13* 70.22 ± 35 < 0.001 0.49 0.84
HDL (mg/dl) 52.08 ± 8.68 62.08 ± 10.61* 10 ± 8.37 54.69 ± 12.86 64.22 ± 15.78* 9.52 ± 11.39 < 0.001 0.36 0.84
LDL (mg/dl) 81.98 ± 20.93 118.67 ± 37.38* 36.68 ± 29.93 84.08 ± 26.06 118.53 ± 23.89* 34.45 ± 27.39 < 0.001 0.86 0.74
LDL/HDL-C 1.58 ± 0.36 1.90 ± 0.44* 0.31 ± 0.44 1.56 ± 0.45 1.91 ± 0.46* 0.35 ± 0.47 < 0.001 0.92 0.76
TC/HDL-C 2.97 ± 0.44 3.71 ± 0.49* 0.73 ± 0.51 2.93 ± 0.55 3.67 ± 0.63* 0.73 ± 0.52 < 0.001 0.68 0.99
Calcium (mg/dl) 9.47 ± 0.38 8.97 ± 0.37* −0.5 ± 0.41 9.45 ± 0.39 9.01 ± 0.32* −0.43 ± 0.45 < 0.001 0.88 0.51
Phosphate (mg/dl) 4.37 ± 0.45 4.63 ± 1.0 0.26 ± 1.06 4.45 ± 0.62 4.45 ± 0.49 0.0 ± 0.69 0.21 0.67 0.21
iPTH (pg/ml) 17.96 ± 10.60 13.78 ± 7.05* −4.18 ± 7.5 23.51 ± 15.77 15.15 ± 7.68* −8.36 ± 14.17 < 0.001 0.11 0.13
MDA (nmol/mL) 21.17 ± 8.13 17.6 ± 8.7 −1.64 ± 10.42 18.87 ± 8.37 18.17 ± 8.07 1.9 ± 8.36 0.52 0.46 0.26
TAC (g/dL BSA equivalent) 2.99 ± 0.37 2.79 ± 0.58 −0.19 ± 0.67 2.84 ± 0.55 2.78 ± 0.45 −0.06 ± 0.62 0.18 0.51 0.50
  1. aAll values are expressed as means±SD (standard deviation)
  2. 2Resulted from 1-factor repeated measures ANOVA
  3. *different from baseline, p < 0.05
  4. **difference of changes between groups, P-interaction< 0.05
  5. bTime×Group: Time means from the first to the last visit of intervention and group means comparison between the two groups of intervention
  6. 25(OH)D3 25-hydroxyvitamin D3, FBS fasting serum glucose, TC total cholesterol, TG triglycerides, LDL low-density lipoprotein, HDL high-density lipoprotein, iPTH intact parathyroid hormone, MDA malondialdehyde, TAC total antioxidant capacity, HOMA-IR homeostasis model assessment of insulin resistance