Fetal sex and maternal insulin resistance during mid-pregnancy: a retrospective cohort study

Table 3 Comparison of the indices of maternal insulin dynamics at 24–34 weeks of gestation between the groups

	Male group (n = 338)	Female group (n = 279)	Crude P value	Adjusted* P value
FIRI (µU/mL)	6.2 (4.6–8.8)	7.0 (5-9.6)	0.0090	0.0061
HOMA-IR	1.24 (0.89–1.86)	1.41 (1.01–1.98)	0.012	0.014
IsOGTT	6.29 (4.59–8.84)	5.86 (4.29–7.83)	0.025	0.0072
HOMA-ß	135 (97–181)	138 (105–198)	0.14	0.058
IGI	0.61 (0.40–0.90) (n = 174)	0.60 (0.41–0.92) (n = 142)	0.95	0.83
AUC of the total IRI (µU x hours/mL)	90 (62–127)	90 (67–128)	0.36	0.068
AUC of the increase of IRI (µU x hours/mL)	76 (52–111)	77 (55–109)	0.43	0.11

* Adjusted for maternal age, pre-pregnancy BMI, gestational age and fasting PG at OGTT, and GDM diagnosis category
Data are expressed as median (quartile range)
FIRI Fasting immunoreactive insulin, HOMA-IR Homeostasis assessment model–insulin resistance, IsOGTT Insulin sensitivity index, IGI Insulinogenic index, AUC Area under the curve, IRI Immunoreactive insulin

ISSN: 1471-2393