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Table 2 AGREE II standardized domain scores for the included CPGs

From: Quality assessment of evidence-based clinical practice guidelines for the management of pregnant women with sickle cell disease using the AGREE II instrument: a systematic review

CPGs/ AGREE II Domains-standardized scores (%) ACOG 2018[22] NICE 2016[23] RCOG 2018[24] NHLBI 2014[25]
Domain 1. Scope and purpose
Items 1–3: Objectives; Health question(s); Population (patients, public, etc.).
76% 93% 89% 88%
Domain 2. Stakeholder Involvement
Items 4–6: Group Membership; Target population preferences and views; Target users
33% 85% 76% 64%
Domain 3. Rigor of development
Items 7–14: Search methods; Evidence selection criteria; Strengths and limitations of the evidence; Formulation of recommendations; Consideration of benefits and harms; Link between recommendations and evidence; External review; Updating procedure
41% 90% 73% 71%
Domain 4. Clarity and presentation
Items 15–17: Specific and unambiguous recommendations; Management options; Identifiable key recommendations
63% 89% 83% 83%
Domain 5. Applicability
Items 18–21: Facilitators and barriers to application; Implementation advice/ tools; Resource implications; Monitoring/ auditing criteria
24% 90% 46% 47%
Domain 6. Editorial independence
Items 22, 23: Funding body; Competing interests
19% 71% 77% 52%
Overall Assessment 1
(Overall quality)
46% 83% 79% 83%
Overall Assessment 2
(Recommend the CPG for use by the four appraisers)
Yes (n = 1); Yes with modifications (n = 2); No (n = 1). Yes (n = 1); Yes with modifications (n = 3); No (n = 0). Yes (n = 2); Yes with modifications (n = 2); No (n = 0). Yes (n = 3); Yes with modifications (n = 1); No (n = 0).
  1. Abbreviations: ACOG American College of Obstetricians and Gynecologists; AGREE II Appraisal of Guidelines for Research and Evaluation II; CPG clinical practice guideline or guidance; NICE National Institute of Health and Care Excellence; NHLBI National Institutes of Health, National Heart, Lung, and Blood Institute; and RCOG Royal College of Obstetricians and Gynaecologists