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Table 2 AGREE II standardized domain scores for the included CPGs

From: Quality assessment of evidence-based clinical practice guidelines for the management of pregnant women with sickle cell disease using the AGREE II instrument: a systematic review

CPGs/ AGREE II Domains-standardized scores (%)

ACOG 2018[22]

NICE 2016[23]

RCOG 2018[24]

NHLBI 2014[25]

Domain 1. Scope and purpose

Items 1–3: Objectives; Health question(s); Population (patients, public, etc.).

76%

93%

89%

88%

Domain 2. Stakeholder Involvement

Items 4–6: Group Membership; Target population preferences and views; Target users

33%

85%

76%

64%

Domain 3. Rigor of development

Items 7–14: Search methods; Evidence selection criteria; Strengths and limitations of the evidence; Formulation of recommendations; Consideration of benefits and harms; Link between recommendations and evidence; External review; Updating procedure

41%

90%

73%

71%

Domain 4. Clarity and presentation

Items 15–17: Specific and unambiguous recommendations; Management options; Identifiable key recommendations

63%

89%

83%

83%

Domain 5. Applicability

Items 18–21: Facilitators and barriers to application; Implementation advice/ tools; Resource implications; Monitoring/ auditing criteria

24%

90%

46%

47%

Domain 6. Editorial independence

Items 22, 23: Funding body; Competing interests

19%

71%

77%

52%

Overall Assessment 1

(Overall quality)

46%

83%

79%

83%

Overall Assessment 2

(Recommend the CPG for use by the four appraisers)

Yes (n = 1); Yes with modifications (n = 2); No (n = 1).

Yes (n = 1); Yes with modifications (n = 3); No (n = 0).

Yes (n = 2); Yes with modifications (n = 2); No (n = 0).

Yes (n = 3); Yes with modifications (n = 1); No (n = 0).

  1. Abbreviations: ACOG American College of Obstetricians and Gynecologists; AGREE II Appraisal of Guidelines for Research and Evaluation II; CPG clinical practice guideline or guidance; NICE National Institute of Health and Care Excellence; NHLBI National Institutes of Health, National Heart, Lung, and Blood Institute; and RCOG Royal College of Obstetricians and Gynaecologists