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Table 6 The potential correlation of ANO8 mutations with clinical and laboratory data in samples from 151 Han Chinese patients with ICP disease

From: Whole-exome sequencing reveals ANO8 as a genetic risk factor for intrahepatic cholestasis of pregnancy

Featuresa

ICP without ANO8 mutations

ICP with ANO8 mutations

P value

Basic information

  Age (years, mean ± SD, Nb)

29.43 ± 5.31 (n = 143)

28.5 ± 3.43 (n = 08)

0.62

  BMI (kg/m2)

25.82 ± 3.37 (n = 129)

25.36 ± 3.62 (n = 08)

0.71

Laboratory, mean (range, N)

  K (mmol/L)

4.00 (3.20–4.90, 134)

3.94 (3.6–4.3, 7)

0.61

  Na (mmol/L)

137.47 (132.00–143.00, 133)

136.71 (134.00–139.00, 7)

0.41

  CL (mmol/L)

104.17 (97.00–112.00, 133)

102.71 (100.00–104.00, 7)

0.17

  Ca (mmol/L)

2.31 (2.00–2.90, 133)

2.33 (2.23–2.48, 7)

0.71

  Mg (mmol/L)

0.81 (0.60–1.89, 133)

0.79 (0.70–0.87, 7)

0.36

  P (mmol/L)

1.12 (0.72–1.60, 133)

1.04 (0.70–1.30, 7)

0.21

  WBC (× 109)

8.61 (4.37–24.23, 142)

7.75 (5.90–10.03, 8)

0.40

  RBC (× 1012)

3.85 (2.96–4.98, 142)

3.59 (3.25–4.02, 8)

0.08

  PLT (× 109)

197.61 (75.00–412.00, 142)

212.25 (112.00–328.00, 8)

0.52

  RDW-SD (fL)

45.93 (36.20–67.30, 142)

44.30 (39.70–49.30, 8)

0.34

  TBA (µmol/L)

40.81 (4.20–286.80, 143)

93.36 (14.80–185.50, 8)

0.038

  CHOL (mmol/L)

6.41 (3.35–10.95, 137)

6.40 (4.91–8.75, 7)

0.98

  TG (mmol/L)

3.59 (1.20–10.44, 137)

3.88 (1.56–11.10, 7)

0.82

  Birth weight (kg)

3.06 (1.23–5.30, 112)

2.86 (2.45–3.35, 5)

0.36

  Bleeding amount (ml)

251.74 (90.00 − 810.00, 109)

310.00 (190.00–600.00, 5)

0.48

  1. aSee the footnotes in Table 1
  2. bN: total number