Whole-exome sequencing reveals ANO8 as a genetic risk factor for intrahepatic cholestasis of pregnancy

Table 1 Descriptive statistics of 27 clinical data points in 151 Han patients with ICP disease

Features	N	Mean	SD	Min.	Max.
Basic information
Age (years)	151	29.38	5.24	17	43
Gestational age (days)	127	263.43	15.90	215	290
BMI (kg/m²)	137	25.79	4.03	19.6	38.5
Ion Concentration
K (mmol/L)	141	4.00	0.31	3.2	4.9
Na (mmol/L)	140	137.44	2.37	132	143
Cl (mmol/L)	140	104.10	2.80	97	112
Ca (mmol/L)	140	2.31	0.15	2	2.9
Mg (mmol/L)	140	0.81	0.15	0.6	1.89
P (mmol/L)	140	1.12	0.18	0.7	1.6
Routine blood test
WBC (× 10⁹)	150	8.56	2.84	4.37	24.23
RBC (× 10⁹)	150	3.84	0.42	2.96	4.98
PLT (× 10⁹)	150	198.39	62.68	75	412
RDW-SD (fL)	150	45.84	4.68	36.2	67.3
Liver function index
ALT (U/L)	139	102.46	127.03	7	595
AST (U/L)	140	86.73	96.28	15	456
TBA (µmol/L)	151	42.99	39.11	4.2	286.8
TBIL (µmol/L)	149	14.88	7.60	5.7	64.8
DBIL (µmol/L)	149	6.45	5.96	0.9	49.5
IDBIL (µmol/L)	149	8.46	3.58	2.9	26.9
Lipid index
CHOL (mmol/L)	144	6.41	1.51	3.35	10.95
TG (mmol/L)	144	3.61	1.56	1.2	11.1
HDL (mmol/L)	144	1.91	0.44	0.92	4.06
LDL (mmol/L)	144	2.86	1.28	0.13	6.28
UA (µmol/L)	141	319.58	81.70	111	574
Outcomes of pregnant women and newborns
Bleeding amount (ml)	114	254.30	103.26	90	810
Apgar score (1–10)	117	9.38	1.08	6	10
Birth weight (kg)	118	3.05	0.75	1.23	5.3

BMI Body mass index, WBC White blood cell, RBC Red blood cell, PLT Platelet, RDW-SD Red blood cell distribution width SD, ALT Alanine transaminase, AST Aspartate transaminase, TBA Total bile acid, TBIL Total bilirubin, DBIL Direct bilirubin, IDBIL Indirect bilirubin, CHOL Total cholesterol, TG Triglyceride, HDL High-density lipoprotein, LDL Low-density lipoprotein, UA Uric acid

ISSN: 1471-2393