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Table 3 Risk factors for HDF in foetuses with maternal alloimmunization

From: Distribution of maternal red cell antibodies and the risk of severe alloimmune haemolytic disease of the foetus in a Chinese population: a cohort study on prenatal management

 

HDF

(n = 120)

No HDF

(n = 145)

P

Univariable OR

(95% CI)

P

Multivariable ORb

(95% CI)

Previous affected pregnancies per womana

1(0–2)

0 (0–0)

<0.001

5.66(3.561–9.006)

<0.001

5.34(3.156–9.036)

Maternal transfusion history, n (%)

18(15.0)

21(14.5)

0.906

0.96(0.485–1.898)

0.021

3.74(1.219–11.464)

Maternal antibody titrea

1:512(1:256-1:1792)

1:64(1:16 − 1:256)c

<0.001

1.00(1.001–1.002)

<0.001

1.00(1.001–1.002)

Major ABO incompatibility, n (%)

9(7.7)d

26(19.8)e

0.319

0.72(0.376–1.375)

0.488

0.73(0.303–1.767)

Types of maternal antibody

 Anti-D, n (%)

82(68.3)

121(83.4)

-

-

-

-

 Anti-D combined with others, n (%)

23(19.1)

15(10.3)

0.024

2.26(1.114–4.594)

0.598

0.74(0.246–2.246)

 Other single-antibody, n (%)

15(12.5)

9(4.8)

0.043

2.46(1.028–5.886)

0.042

3.25(1.043–10.114)

  1. HDF haemolytic disease of the foetus
  2. aData present as median (25th − 75th quartiles)
  3. bThe multivariable analysis included the following risk factors for analysis: previous affected pregnancies per woman, maternal transfusion history, maternal antibody titre, major ABO incompatibility and types of maternal antibody (anti-D, other single-antibody)
  4. cAssessed in 135/145 (93.1%) foetuses, missing values for 10
  5. dAssessed in 117/120 (97.5%) foetuses, missing values for 3
  6. eAssessed in 131/145 (90.3%) foetuses, missing values for 14