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Table 1 Patient characteristics collected within the VR FETUS study. Details of data collection form the first trimester up to 6 weeks after delivery are depicted

From: First trimester anomaly scan using virtual reality (VR FETUS study): study protocol for a randomized clinical trial

Maternal Characteristics Outcome
Age Years (mean ± SD)
Ethnicity Dutch/Other western/Non-western
Level of education Low, middle, high
Postal code  
Medical history Unremarkable/Diabetes/Epilepsy/Other
Obstetrical history Parity, miscarriage, previous pregnancy with congenital anomaly
Family history Unremarkable/family members with congenital anomaly
Marital status Married/not married
Global household income €0–20.000/€20.000–35.000/€35.000–65.000/>€65.000 annually
BMI Kg/m2 (mean ± SD)
Alcohol use during first trimester No/Yes: how many units per day?
Smoking during first trimester No/yes: how many cigarettes per day
Recreational drug use during first trimester No/yes: what drugs; frequency per day?
Folic acid use during and/or prior to pregnancy No/yes during pregnancy/yes started prior to pregnancy
Pregnant after artificial reproductive technology No/yes: what type of assisted reproduction
First trimester screening for aneuploidy No/yes: result
Medication No/yes: what medication, dosage, starting and stopping date?
Antidepressant Never/yes currently/yes previous use
Questionnaires Timing
Current health statusa At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date
Anxiety and depressionb At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date
State and trait anxietyc At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date
Current health status by VASd At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date
Medical consumptione At 20 weeks’ GA, 32 weeks’ GA, 6 weeks after due date
Patient satisfaction with 3D VR At intervention or 13 weeks’ GA, 6 weeks after due date
Ultrasound Measurements
At inclusion, 1st trimester Viability, CRL, multiple pregnancies, location
Intervention: 2D + 3D VR First Trimester Ultrasound, 1st trimester Fetal anomaly scan using 2D and 3D VR. Growth parameters, detection of anomaly. See supplement A
Advanced fetal anomaly scan, 2nd trimester Fetal anomaly scan using 2D. Growth parameters, detection of anomaly
Pregnancy outcome Outcome
Outcome Live birth, termination, intra-uterine fetal demise
Mode of delivery Vaginal / Instrumental delivery / Cesarean section
Gestational age at delivery Days (mean ± SD)
Invasive testing No/yes: result
Date of invasive testing  
Neonatal outcome Outcome
Birthweight Birthweight, grams (mean ± SD)
Gender Male/female
Congenital malformation No/yes: what malformation
Prenatal diagnosis Confirmed/discrepancy in findings: postnatal new or other findings
  1. aSF-36: MOS 36-item Short Form Health Survey, bHADS: Hospital Anxiety and Depression Scale, cSTAI: Spielberger State-Trait Anxiety Inventory, dVAS: visual analogue scale, eiMTA MCQ: iMTA Medical Consumption Questionnaire, CRL: Crown-Rump Length, 2D: two-dimensional, 3D VR: three-dimensional virtual reality