Table 1 Patient characteristics collected within the VR FETUS study. Details of data collection form the first trimester up to 6 weeks after delivery are depicted
Maternal Characteristics | Outcome |
Age | Years (mean ± SD) |
Ethnicity | Dutch/Other western/Non-western |
Level of education | Low, middle, high |
Postal code | Â |
Medical history | Unremarkable/Diabetes/Epilepsy/Other |
Obstetrical history | Parity, miscarriage, previous pregnancy with congenital anomaly |
Family history | Unremarkable/family members with congenital anomaly |
Marital status | Married/not married |
Global household income | €0–20.000/€20.000–35.000/€35.000–65.000/>€65.000 annually |
BMI | Kg/m2 (mean ± SD) |
Alcohol use during first trimester | No/Yes: how many units per day? |
Smoking during first trimester | No/yes: how many cigarettes per day |
Recreational drug use during first trimester | No/yes: what drugs; frequency per day? |
Folic acid use during and/or prior to pregnancy | No/yes during pregnancy/yes started prior to pregnancy |
Pregnant after artificial reproductive technology | No/yes: what type of assisted reproduction |
First trimester screening for aneuploidy | No/yes: result |
Medication | No/yes: what medication, dosage, starting and stopping date? |
Antidepressant | Never/yes currently/yes previous use |
Questionnaires | Timing |
Current health statusa | At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date |
Anxiety and depressionb | At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date |
State and trait anxietyc | At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date |
Current health status by VASd | At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date |
Medical consumptione | At 20 weeks’ GA, 32 weeks’ GA, 6 weeks after due date |
Patient satisfaction with 3D VR | At intervention or 13 weeks’ GA, 6 weeks after due date |
Ultrasound | Measurements |
At inclusion, 1st trimester | Viability, CRL, multiple pregnancies, location |
Intervention: 2D + 3D VR First Trimester Ultrasound, 1st trimester | Fetal anomaly scan using 2D and 3D VR. Growth parameters, detection of anomaly. See supplement A |
Advanced fetal anomaly scan, 2nd trimester | Fetal anomaly scan using 2D. Growth parameters, detection of anomaly |
Pregnancy outcome | Outcome |
Outcome | Live birth, termination, intra-uterine fetal demise |
Mode of delivery | Vaginal / Instrumental delivery / Cesarean section |
Gestational age at delivery | Days (mean ± SD) |
Invasive testing | No/yes: result |
Date of invasive testing | Â |
Neonatal outcome | Outcome |
Birthweight | Birthweight, grams (mean ± SD) |
Gender | Male/female |
Congenital malformation | No/yes: what malformation |
Prenatal diagnosis | Confirmed/discrepancy in findings: postnatal new or other findings |