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Table 4 Logistic regression analysis with euthyroid women with TPOAb positivity as independent variables and poor pregnancy and fetal outcomes as categorical dependent variables

From: Relationship between anti-thyroid peroxidase antibody positivity and pregnancy-related and fetal outcomes in Euthyroid women: a single-center cohort study

GDM

Total

Pregnant women with a female fetus

Pregnant women with a male fetus

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

p

Model 1

0.991 (0.558–1.760)

0.975

0.596 (0.239–1.483)

0.239

1.696 (0.801–3.591)

0.168

Model 2

1.282 (0.610–2.694)

0.512

0.690 (0.215–2.218)

0.534

2.349 (0.831–6.638)

0.107

Spontaneous abortion

 Model 1

1.925 (0.709–5.222)

0.199

    

 Model 2

1.083 (0.227–5.171)

0.920

    

PROM

 Model 1

0.757 (0.399–1.436)

0.383

0.641 (0.239–1.717)

0.197

0.914 (0.386–2.168)

0.914

 Model 2

0.476 (0.181–1.250)

0.132

0.835 (0.264–2.640)

0.758

0.391 (0.084–1.831)

0.233

Preterm Birth

 Model 1

1.765 (0.713–4.370)

0.219

3.650 (1.195–11.154)

0.023*

1.487 (0.415–5.328)

0.543

 Model 2

2.202 (0.699–6.937)

0.178

4.511 (1.075–18.926)

0.04*

0.856 (0.103–7.116)

0.886

Fetal distress

 Model 1

1.680 (0.755–3.736)

0.204

2.669 (0.999–7.129)

0.05

0.826 (0.183–3.734)

0.804

 Model 2

1.084 (0.307–3.820)

0.900

1.902 (0.371–9.472)

0.440

0.769 (0.091–6.487)

0.809

Low Birth weight

 Model 1

1.233 (0.480–3.171)

0.663

1.117 (0.246–5.074)

0.886

1.887 (0.394–9.023)

0.427

 Model 2

1.128 (0.251–5.073)

0.875

0.617 (0.072–5.314)

0.661

2.467 (0.486–12.532)

0.276

Fetal macrosomia

 Model 1

0.413 (0.098,1.745)

0.229

0.54 (0.069–4.218)

0.557

0.385 (0.050–2.944)

0.358

 Model 2

0.401 (0.094–1.707)

0.216

0.504 (0.63–4.030)

0.518

0.375 (0.049–2.893)

0.347

  1. *P < 0.05
  2. Model 1: Adjusted for age, BMI, parity, and history of spontaneous abortion
  3. Model 2: Additionally, adjusted for HbA1c and TSH
  4. BMI body-mass index, TSH thyroid-stimulating hormone, HbA1c glycated hemoglobin, GDM gestational diabetes, PROM premature rupture of membranes