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Table 2 First (11–13 weeks), second (19–22 weeks) and third (27–30 weeks) trimester evaluation

From: “Screening for small-for-gestational age neonates at early third trimester in a high-risk population for preeclampsia”

  Normal birthweight (n = 328) SGA (n = 50) P
First trimester evaluation
 - Mean uterine artery PI (MoM) 1.2 ± 0.3 1.4 ± 0.3 < 0.001*
 - MAP (mm Hg) 85.8 ± 7.9 82.0 ± 7.1 0.002*
 - PAPP-A (MoM) 1 ± 0.5 0.8 ± 0.4 0.039*
 - PlGF (MoM) 0.3 ± 0.2 0.2 ± 0.2 0.002*
Second trimester evaluation
 - Mean uterine artery PI (MoM) 1.2 ± 0.6 1.6 ±0.5 < 0.001*
Third trimester evaluation
 - EFW (g) 1399.3 ± 173.2 1244.5 ± 149.0 < 0.001*
 - EFW (z-scores) 0.1 ± 1.0 -0.7 ± 0.9 < 0.001*
 - Mean uterine artery PI (MoM) 1.2 ± 0.4 1.4 ± 0.5 < 0.001*
 - MAP (mmHg) 81.9 ± 10.3 80.5 ± 9.9 0.372
 - PlGF (pg/mL) 530.9 ± 423.1 328.4 ± 287.8 < 0.001*
 - PlGF (MoM) 1.13 ± 0.9 0.70 ± 0.62 < 0.001*
 - sFlt-1 (pg/mL) 1385.5 ± 1118.7 1692.5 ± 1206.7 0.037*
 - sFlt-1 (MoM) 0.9 ± 0.7 1.1 ± 0.8 0.037*
 - sFlt-1/PlGF 6.2 ± 17.1 14.7 ± 21.7 < 0.001*
 - sFlt-1/PlGF (MoM) 1.8 ± 5.2 4.5 ± 6.8 < 0.001*
  1. Quantitative variables were expressed as mean ± SD
  2. (*p < 0.05)
  3. SGA Small-for-gestational age neonates, PI Pulsatility index, MoM Multiples of the median, MAP Mean arterial pressure, PAPP-A Pregnancy-associated plasma protein A, PlGF Placental growth factor, EFW Estimated fetal weight, sFlt-1 Soluble FMS-Like Tyrosine Kinase-1