From: Pregnancy induced Cushing’s syndrome and primary aldosteronism: a case report
Case | Presentation | Therapy and Imaging | Outcome |
---|---|---|---|
Kasperlik-Zaluska 2000 [1] | Hypertension (190/110 mmHg), muscular atrophy, purple striae, hirsutism, hypokalemia at 16 weeks | None described | Cesarean section 24th week due placental abruption, postpartum lab values normal after 4 weeks |
Kasperlik-Zaluska 2000 [1] | Similar features with elevated UFC at 16 weeks | None described | Cesarean section 25th week due to placental abruption, postpartum lab values normal after 3 months |
Kasperlik-Zaluska 2000 [1] | Elevated UFC at 5 weeks, no symptoms | Metyrapone 0.75 g daily until 17 weeks, then increased to 1 gram due to increasing cortisol | Cesarean section at 32nd week due to placental abruption, normalization of lab values beginning at 2 weeks postpartum |
Close 1993 [5] | Elevated cortisol, UFC and CS at 23 weeks | Bilateral adrenal hyperplasia in CT, Metyrapone | Cesarean section at 34 weeks by growth retardation, normal lab values at 4 weeks postpartum |
Andreescu 2017 [6] | Purple striae, bruising, hypertension (165/90 mmHg), mild hypokalemia, proteinuria at 32 weeks, elevated UFC | Enalapril 40 mg daily Labetalol 600 mg daily CT: 3.8 cm Adenoma, LH receptor positive (immunohistochemical examination) | Induction of Labor at 35 weeks, Adrenalectomy and hydrocortisone replacement 4 months postpartum |
Andreescu 2017 [6] | Hypertension (140/86 mmHg), purple striae, hirsutism, diabetes mellitus | Labetalol 400 mg daily MRI: 3.3 cm Adenoma, LH receptor positive (immunohistochemical examination) | Spontaneous labor and vaginal delivery 38 weeks, Adrenalectomy and hydrocortisone around 4 months postpartum |
Andreescu 2017 [6] | Gestational diabetes, depression, hirsutism, bruising | Paroxetine 20 mg daily CT: 3.4 cm Adenoma (no immunohistochemical examination performed) | Spontaneous labor and vaginal delivery at 38 weeks, Adrenalectomy and hydrocortisone 6 months postpartum |