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Table 2 Summary of pregnancy induced CS cases

From: Pregnancy induced Cushing’s syndrome and primary aldosteronism: a case report

Case Presentation Therapy and Imaging Outcome
Kasperlik-Zaluska 2000 [1] Hypertension (190/110 mmHg), muscular atrophy, purple striae, hirsutism, hypokalemia at 16 weeks None described Cesarean section 24th week due placental abruption, postpartum lab values normal after 4 weeks
Kasperlik-Zaluska 2000 [1] Similar features with elevated UFC at 16 weeks None described Cesarean section 25th week due to placental abruption, postpartum lab values normal after 3 months
Kasperlik-Zaluska 2000 [1] Elevated UFC at 5 weeks, no symptoms Metyrapone 0.75 g daily until 17 weeks, then increased to 1 gram due to increasing cortisol Cesarean section at 32nd week due to placental abruption, normalization of lab values beginning at 2 weeks postpartum
Close 1993 [5] Elevated cortisol, UFC and CS at 23 weeks Bilateral adrenal hyperplasia in CT, Metyrapone Cesarean section at 34 weeks by growth retardation, normal lab values at 4 weeks postpartum
Andreescu 2017 [6] Purple striae, bruising, hypertension (165/90 mmHg), mild hypokalemia, proteinuria at 32 weeks, elevated UFC Enalapril 40 mg daily Labetalol 600 mg daily
CT: 3.8 cm Adenoma, LH receptor positive (immunohistochemical examination)
Induction of Labor at 35 weeks, Adrenalectomy and hydrocortisone replacement 4 months postpartum
Andreescu 2017 [6] Hypertension (140/86 mmHg), purple striae, hirsutism, diabetes mellitus Labetalol 400 mg daily
MRI: 3.3 cm Adenoma, LH receptor positive (immunohistochemical examination)
Spontaneous labor and vaginal delivery 38 weeks, Adrenalectomy and hydrocortisone around 4 months postpartum
Andreescu 2017 [6] Gestational diabetes, depression, hirsutism, bruising Paroxetine 20 mg daily
CT: 3.4 cm Adenoma (no immunohistochemical examination performed)
Spontaneous labor and vaginal delivery at 38 weeks, Adrenalectomy and hydrocortisone 6 months postpartum