Skip to main content

Table 2 Meta-regression analysis of HEV infection prevalence in global population of pregnant women

From: Burden of hepatitis E virus infection in pregnancy and maternofoetal outcomes: a systematic review and meta-analysis

Variables (reference)

Univariable model

Explained variance, R2

Multivariable model

Prevalence odds ratio (95% confidence intervals)

P value

P value, test for moderator

Adjusted prevalence odds ratio (95% confidence intervals)

P value

Clinical presentation (asymptomatic)

  

<  0.0001

76.1%

  

 Symptomatic

1.79 (1.64–1.97)

<  0.0001

  

1.76 (1.61–1.91)

<  0.0001

Year of publication

  

0.012

9.8%

  

 By increase of 10 years

0.84 (0.73–0.96)

0.012

  

0.90 (0.84–0.96)

0.003

Human development index (high and very high)

  

<  0.0001

24.6%

  

 Low and medium

1.62 (1.35–1.95)

<  0.0001

    

Regions (Africa)

  

<  0.0001

65.3%

  

 Americas

0.93 (0.71–1.22)

0.615

    

 Eastern Mediterranean

1.16 (0.96–1.39)

0.132

    

 Europe

0.80 (0.62–1.04)

0.092

    

 South-East Asia

1.71 (1.46–2.00)

<  0.0001

    

 Western Pacific

0.96 (0.74–1.24)

0.744

    

Country HEV endemic profile (low)

  

0.031

0.0%

  

 Endemic

0.91 (0.55–1.50)

0.717

    

 High

1.37 (0.98–1.92)

0.069

    

Sampling (non-probability-based)

  

0.734

0.0%

  

 Probability-based

1.11 (0.68–1.79)

0.682

    

 Unclear

1.07 (0.89–1.29)

0.460