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Table 2 Meta-regression analysis of HEV infection prevalence in global population of pregnant women

From: Burden of hepatitis E virus infection in pregnancy and maternofoetal outcomes: a systematic review and meta-analysis

Variables (reference) Univariable model Explained variance, R2 Multivariable model
Prevalence odds ratio (95% confidence intervals) P value P value, test for moderator Adjusted prevalence odds ratio (95% confidence intervals) P value
Clinical presentation (asymptomatic)    <  0.0001 76.1%   
 Symptomatic 1.79 (1.64–1.97) <  0.0001    1.76 (1.61–1.91) <  0.0001
Year of publication    0.012 9.8%   
 By increase of 10 years 0.84 (0.73–0.96) 0.012    0.90 (0.84–0.96) 0.003
Human development index (high and very high)    <  0.0001 24.6%   
 Low and medium 1.62 (1.35–1.95) <  0.0001     
Regions (Africa)    <  0.0001 65.3%   
 Americas 0.93 (0.71–1.22) 0.615     
 Eastern Mediterranean 1.16 (0.96–1.39) 0.132     
 Europe 0.80 (0.62–1.04) 0.092     
 South-East Asia 1.71 (1.46–2.00) <  0.0001     
 Western Pacific 0.96 (0.74–1.24) 0.744     
Country HEV endemic profile (low)    0.031 0.0%   
 Endemic 0.91 (0.55–1.50) 0.717     
 High 1.37 (0.98–1.92) 0.069     
Sampling (non-probability-based)    0.734 0.0%   
 Probability-based 1.11 (0.68–1.79) 0.682     
 Unclear 1.07 (0.89–1.29) 0.460