Variable | Quintile for Ca | p-value | ||||
---|---|---|---|---|---|---|
Q1 (low) | Q2 | Q3 | Q4 | Q5 (High) | ||
n = 6829 | n = 6733 | n = 6800 | n = 6763 | n = 6769 | ||
Maternal medical background | ||||||
Ca intake before pregnancy mg/day median (inter-quartile range) | 199 (154–235) | 321 (295–347) | 430 (401–460) | 567 (529–613) | 899 (755–1253) | < 0.001a |
Maternal age, years mean (SD) | 28.5 (5.1) | 29.9 (5.1) | 30.4 (5.0) | 30.7 (4.9) | 30.8 (5.1) | < 0.001b |
Advanced maternal age, % | 13.4 | 19.2 | 21.3 | 22.9 | 24.2 | < 0.001c |
Pre-pregnancy BMI (kg/m2), % | ||||||
< 18.5 | 19.1 | 18.4 | 16.2 | 16.7 | 16.1 | < 0.001c |
18.5 to 25.0 | 71.4 | 72.4 | 75.3 | 75.0 | 76.2 | |
> 25.0 | 9.5 | 9.2 | 8.6 | 8.4 | 7.7 | |
Smoking during pregnancy, % | 5.5 | 3.5 | 3.1 | 2.6 | 2.7 | < 0.001c |
Sterility treatment, % | 7.3 | 10.7 | 10.8 | 11.5 | 12.2 | < 0.001c |
Maternal education, year, % | ||||||
< 10 | 5.8 | 3.6 | 2.6 | 2.3 | 2.5 | < 0.001c |
10 to 12 | 36.7 | 29.9 | 25.8 | 24.3 | 24.8 | |
13 to 16 | 39.6 | 43.0 | 43.2 | 43.2 | 43.9 | |
more than 17 | 17.7 | 23.6 | 28.5 | 30.2 | 28.8 | |
Household income, JPY, % | ||||||
<2,000,000 | 8.1 | 5.7 | 4.7 | 4.4 | 4.8 | < 0.001c |
2,000,000–5,999,999 | 69.5 | 66.4 | 65.6 | 64.1 | 64.1 | |
6,000,000–9,999,999 | 19.5 | 23.7 | 24.9 | 26.4 | 25.7 | |
≥10,000,000 | 3.0 | 4.2 | 4.9 | 5.1 | 5.3 | |
Obstetric outcome | ||||||
HDP, % | 3.1 | 3.4 | 3.5 | 3.2 | 3.1 | 0.719d |
Eo-HDP, % | 0.5 | 0.7 | 0.5 | 0.5 | 0.6 | 0.739d |
Lo-HDP, % | 2.3 | 2.4 | 2.6 | 2.4 | 2.2 | 0.655d |
PTB < 37 wks, % | 4.4 | 3.9 | 4.5 | 4.2 | 4.0 | 0.322d |
LBW < 2500 g, % | 9.7 | 8.6 | 8.7 | 9.0 | 8.9 | 0.213d |