Association between prepregnancy body mass index and risk of congenital heart defects in offspring: an ambispective observational study in China

Table 3 Multilevel logistic regression to identify interactions between maternal prepregnancy BMI and subtypes of CHD in offspring ^a

CHD subtype	Total cases, n	mOR (95%CI) in subgroups based on maternal prepregnancy BMI
CHD subtype	Total cases, n	Subgroup cases, n	Underweight (BMI < 18.5)	Subgroup cases, n	Low average weight (18.5 ≤ BMI < 21.25)	Subgroup cases, n	Overweight (BMI ≥ 24.0)
SPD	238	66	1.90 (1.11,3.26)	107	1.63 (0.99,2.67)^†	15	0.96 (0.43,2.13)
VSD	157	48	2.03 (1.06,3.88)	70	1.46 (0.81,2.65)	5	0.51 (0.16,1.62)
Other^b	81	18	1.53 (0.66,3.52)	37	1.58 (0.75,3.33)	10	1.59 (0.56,4.52)
CTD	255	62	1.23 (0.73,2.09)	122	1.60 (1.01,2.53)	17	0.83 (0.37,1.88)
LVOTO	82	21	1.52 (0.66,3.54)	37	1.40 (0.64,3.04)	10	1.37 (0.45,4.20)
RVOTO	81	24	1.75 (0.75,4.12)	33	1.33 (0.60,2.93)	7	1.83 (0.60,5.58)
AVR	29	10	2.59 (0.69,9.73)	12	1.87 (0.54,6.52)	3	2.77 (0.53,14.30)
ELSE	30	8	1.63 (0.47,5.71)	15	0.88 (0.26,2.97)	1	0.66 (0.07,6.15)

SPD septal defect, VSD ventricular septal defect, CTD conotruncal defect, LVOTO left ventricular outflow tract obstruction, RVOTO right ventricular outflow tract obstruction, AVR anomalous venous return, ELSE other cardiac structure abnormalities. ^a Only cases with a single CHD were included. Odds ratios were adjusted for the factors shown in Table 1. Hospital was set as a random intercept effect. ^b Cases of the atrial septal defects (n = 21) and other septal defects excluding atrial septal defects (n = 60) were aggregated because of the small numbers of subjects. ^†p < 0.10

ISSN: 1471-2393