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Table 3 Clinical outcomes in NGS-PGT-A group and SNP-PGT-A group

From: Improved clinical outcomes of preimplantation genetic testing for aneuploidy using MALBAC-NGS compared with MDA-SNP array

Clinical measures NGS based PGT-A SNP array based PGT-A P-value
No. of couples participating 805 613  
No. of couples with transfer 522 440  
No. of couples without available embryos 270 145  
No. of embryos transferred 675 547  
Transferred cycles 675 547  
Maternal age (mean ± SD) of couples with transfer 29.97 ± 4.26 29.78 ± 4.42 0.489
PGT-A indications
 Robertsonian translocation 21.3%(111/522) 19.5%(86/440) 0.510
 Reciprocal translocation 44.6%(233/522) 53.4%(235/440) 0.007*
 Inversion 6.1%(32/522) 2.5%(11/440) 0.007*
 Sex chromosome abnormality 13.8%(72/522) 8.6%(38/440) 0.012*
 AMA 5.0%(26/522) 4.5%(20/440) 0.753
 RM 7.5%(39/522) 9.5%(42/440) 0.248
 RIF 1.7%(9/522) 1.8%(8/440) 0.912
Maternal BMI (mean ± SD) of couples with transfer 22.76 ± 3.00 22.70 ± 2.96 0.799
Basal FSH level (mean + SD) of women with transfer 6.51 ± 1.88 6.71 ± 1.80 0.113
Endometrial thickness (mean + SD) a 9.8 ± 1.91 9.7 ± 1.94 0.544
Clinical pregnancy rateb 50.5%(341/675) 41.7%(228/547) 0.002*
Miscarriage rate c 15.5%(54/341) 22.8%(52/228) 0.036*
Healthy baby rated 39.6%(267/675) 31.4%(172/547) 0.003*
  1. aEndometrial thickness measured at embryos transferred day
  2. bClinical pregnancy rate = clinical pregnancy cycles /embryo transferred cycles
  3. cMiscarriage rate = embryo lost cycles /clinical pregnancy cycles
  4. dHealthy baby rate = healthy babies/ number of transferred embryos
  5. *p < 0.05, statistical significance