Improved clinical outcomes of preimplantation genetic testing for aneuploidy using MALBAC-NGS compared with MDA-SNP array

Table 3 Clinical outcomes in NGS-PGT-A group and SNP-PGT-A group

Clinical measures	NGS based PGT-A	SNP array based PGT-A	P-value
No. of couples participating	805	613
No. of couples with transfer	522	440
No. of couples without available embryos	270	145
No. of embryos transferred	675	547
Transferred cycles	675	547
Maternal age (mean ± SD) of couples with transfer	29.97 ± 4.26	29.78 ± 4.42	0.489
PGT-A indications
Robertsonian translocation	21.3%(111/522)	19.5%(86/440)	0.510
Reciprocal translocation	44.6%(233/522)	53.4%(235/440)	0.007*
Inversion	6.1%(32/522)	2.5%(11/440)	0.007*
Sex chromosome abnormality	13.8%(72/522)	8.6%(38/440)	0.012*
AMA	5.0%(26/522)	4.5%(20/440)	0.753
RM	7.5%(39/522)	9.5%(42/440)	0.248
RIF	1.7%(9/522)	1.8%(8/440)	0.912
Maternal BMI (mean ± SD) of couples with transfer	22.76 ± 3.00	22.70 ± 2.96	0.799
Basal FSH level (mean + SD) of women with transfer	6.51 ± 1.88	6.71 ± 1.80	0.113
Endometrial thickness (mean + SD) ^a	9.8 ± 1.91	9.7 ± 1.94	0.544
Clinical pregnancy rate^b	50.5%(341/675)	41.7%(228/547)	0.002*
Miscarriage rate ^c	15.5%(54/341)	22.8%(52/228)	0.036*
Healthy baby rate^d	39.6%(267/675)	31.4%(172/547)	0.003*

^aEndometrial thickness measured at embryos transferred day
^bClinical pregnancy rate = clinical pregnancy cycles /embryo transferred cycles
^cMiscarriage rate = embryo lost cycles /clinical pregnancy cycles
^dHealthy baby rate = healthy babies/ number of transferred embryos
*p < 0.05, statistical significance

ISSN: 1471-2393