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Table 1 Clinical characteristics of the study population

From: Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 – secondary analysis of a randomized controlled trial

Variable

Metformin

n

Insulin

n

p-value

Patients characteristics

 Age (years)

31.9 ± 5.01

109

32.0 ± 5.47

107

0.89

 Smoking

9 (8.6)

105

17 (16.0)

106

0.099

 Primipara

42 (38.5)

109

49 (45.8)

107

0.28

 Pre-pregnancy BMI (kg/m2)

29.5 ± 5.91

109

28.9 ± 4.71

107

0.41

Glucose metabolism

 HbA1c% at OGTT

5.48 ± 0.34

109

5.51 ± 0.34

107

0.49†

 HbA1c at OGTT (mmol/mol)

36.3 ± 3.69

 

36.7 ± 3.72

  

 HbA1c% at 36 gw

5.68 ± 0.33

101

5.69 ± 0.36

95

0.82

 HbA1c at 36 gw (mmol/mol)

38.5 ± 3.63

 

38.6 ± 3.89

  

 OGTT fasting (mmol/L)

5.52 ± 0.55

109

5.57 ± 0.42

107

0.44

 OGTT 1 h (mmol/L)

11.2 ± 1.49

109

11.2 ± 1.24

107

0.61†

 OGTT 2 h (mmol/L)

8.33 ± 1.76

108

7.91 ± 1.75

106

0.076

 C-peptide at baseline (nmol/L)

1.05 ± 0.33

103

1.05 ± 0.29

101

0.90†

Pregnancy outcomes

 Gestational hypertension

2 (1.8)

109

4 (3.7)

107

0.44‡

 Preeclampsia

5 (4.6)

109

10 (9.3)

107

0.19‡

 Assisted vaginal delivery

9 (8.3)

109

8 (7.5)

107

0.83

 Cesarean section

15 (13.8)

109

18 (16.8)

107

0.53

 Induction of labor

41 (37.6)

109

58 (54.2)

107

0.014

 Gestational weight gain (kg)

7.97 ± 5.24

108

7.82 ± 5.27

107

0.83

 Weight gain in late gestation (kg)

1.79 ± 2.62

109

2.15 ± 2.97

107

0.35

 Gw at delivery

39.2 ± 1.40

109

39.4 ± 1.58

107

0.43

Neonatal outcomes

 Birth weight (g)

3610 ± 490

109

3590 ± 450

107

0.78

 Birth weight (SD)

0.17 ± 1.05

105

0.15 ± 0.96

107

0.91

 Birth weight (centiles)

54.8 ± 28.9

105

54.3 ± 28.9

107

 

 Macrosomia

5 (4.6)

109

1 (0.9)

107

0.21‡

 Birth weight < 10th percentile

12 (11.4)

105

9 (8.4)

107

0.46

 Birth weight > 90th percentile

15 (14.3)

105

17 (15.9)

107

0.74

 Admission to NICU

33 (30.1)

108

39 (36.4)

107

0.36

 Newborn I.V. glucose

25 (23.1)

108

25 (23.6)

106

0.94

  1. Data is shown as mean ± SD or n (%). The p-value is given for the t-test or the Mann-Whitney U (indicated with †) and for categorical data for the χ2-test or Fisher’s exact test (indicated with ‡). The number of mothers with clinical variables varied slightly due to missing data for some variables. OGTT = oral glucose tolerance test, gw = gestational weeks, SD = standard deviation, NICU = neonatal intensive care unit, I.V. = intravenous. Birth weight in SD and centiles were adjusted for Finnish population growth charts. Macrosomia was defined as birth weight > 4500 g or > 2 SD