From: Thyroid dysfunction in Iranian pregnant women: a systematic review and meta-analysis
Ref. | First author, Published Year | Year | Place | Number | GAa | Method | Criteria | Quality score |
---|---|---|---|---|---|---|---|---|
[17] | Naghshineh E, 2012 | 2010–11 | Isfahan | 1057 | NR | NR | Hypothyroidism: TSH > 2.50 mIU/L | 7 |
[18] | Mansourian AR, 2010 | 2007–08 | Gorgan | 120 | First trimester | ELISA method for TSH | Hyperthyroidism: TSH < 0.32 mIU/L | 7 |
[19] | Naderi T, 2012 | 2010 | Kerman | 620 | < 20 week | ELISA method for TSH and fT4 | Clinical hypothyroidism: TSH > 4 mIU/L; subclinical hypothyroidism: 2 < TSH < 4 mIU/L and FT4 < 0.07 ng/dL | 8 |
[20] | Dehghani Zahedani M, 2010 | 2007–08 | BandarAbbas | 608 | All trimester | RIA method for TSH and ELISA method for Anti-TPO Ab | clinical hypothyroidism: TSH > 3.5 mIU/L and FT4 < 1.3 ng/dL; subclinical hypothyroidism: TSH > 3.5 mIU/L and FT4 > 1.3 ng/dL; hyperthyroidism: TSH < 0.3 mIU/L and FT4 > 4.6 ng/dL; TPOAb positive: >  75 IU/mL | 8 |
[21] | Borzouei Sh, 2019 | 2015–16 | Hamadan | 852 | First trimester | RIA method for T4, IRMA for TSH and ELISA for anti-Anti-TPO Ab | Clinical hypothyroidism: TSH > 2.5 mIU/L and low FT4 or TSH ≥ 10 mIU/L; subclinical hypothyroidism: TSH > 2.5 mIU/L and normal FT4; subclinical hyperthyroidism: TSH < 0.1 mIU/L and normal (FT4 and FT3); subclinical hyperthyroidism: TSH < 0.1 mIU/L and high (FT4 or FT3); Anti-TPO Ab positive: >  40 IU/mL | 7 |
[22] | Rahmatelahi M, 2016 | 2016–17 | Shahrood | 369 | < 20 week | NR | Clinical hypothyroidism: TSH > 4 mIU/L with low FT4; Subclinical hypothyroidism: TSH > 4 mIU/L with normal FT4; clinical hyperthyroidism: TSH < 0.4 mIU/L and elevated FT4; subclinical hyperthyroidism: TSH level < 0.4 mIU/L and with normal FT4 | 7 |
[23] | Saki F, 2014 | 2011–12 | Shiraz | 586 | 15–18 week | ECL method for TSH and T4 | Clinical hypothyroidism: TSH > 3 mIU/L and low FT4 or TSH ≥ 10 mIU/L; 3 < TSH < 10 mIU/L and normal FT4; clinical hyperthyroidism: TSH < 0.2 mIU/L and elevated FT4 or TSH < 0.1; subclinical hyperthyroidism: 0.1 ≥ TSH ≥ 0.2 mIU/L and normal FT4 | 8 |
[24] | Lotfalizadeh M, 2017 | 2012–13 | Mashhad | 1000 | First trimester | RIA method for TSH and ELISA method for FT4 | Hypothyroidism: TSH > 3 mIU/L | 7 |
[25] | Yassaee F, 2014 | 2008–12 | Tehran | 3158 |  NR | CLIA method for TSH and T4 | Clinical hypothyroidism: TSH > 2.5 mIU/L in the first trimester or TSH > 3 mIU/L in the second or third trimester, with normal FT4 (0.8–1.7 ng/dL); TSH > 2.5 mIU/L and FT4 < 0.8 ng/dL | 8 |
[26] | Mehran L, 2013 | 2004–06 | Tehran | 299 | All trimester | RIA method for of TT4 and TT3 and IRMA method for TSH | Anti-TPO Ab: >  40 IU/mL | 8 |
[27] | Moradi S, 2013 | 2012 | Tehran | 584 | All trimester | IRMA for TSH and by RIA for FT4, T4, T3,T3RU and anti-TPO | The reference range for TSH is 0.2–2.5 mIU/L in the first trimester and 0.3–3.0 mIU/L in the third trimester. | 9 |
[15] | Nazarpour S, 2016 | 2013–14 | Tehran | 1480 | NR | RIA and IRMA methods T4 for TSH | Clinical hypothyroidism: 5 < TSH < 10 mIU/L and FT4 <1 ng/dL or TSH ≥ 10 mIU/L; subclinical hypothyroidism: 2.5 < TSH < 10 mIU/L and 1 < FT4 < 4.5 ng/dL; clinical hyperthyroidism: TSH < 0.02 mIU/L and FT4 > 4.5 ng/dL; subclinical hyperthyroidism: TSH < 0.02 mIU/L and 1< FT4 < 4.5 ng/dL; Anti-TPO Ab positive: > 50 mIU/L | 8 |
[28] | Kianpour M, 2019 | 2017 | Isfahan | 418 | First trimester | NR | hypothyroidism: TSH > 2.5 mIU/L; hyperthyroidism: TSH < 0.1 mIU/L; Anti-TPO Ab positive: >  60 mIU/L | 8 |
[29] | Taghavi M, 2009 | 2006–08 | Mashhad | 500 | First trimester | RIA method for TSH, FT4 and FT3 | TSH level > 4 mIU/L and reduced FT4 concentration as clinical hypothyroidism; TSH level > 4 mIU/L and normal serum FT4 concentration as clinical hypothyroidism; TSH level < 0.4 mIU/L and elevated FT4 concentration as clinical hyperthyroidism | 8 |
[30] | Nazarpour S, 2018 | 2013–16 | Tehran | 1843 | First trimester | RIA method for T4 and IRMA method for TSH and IEMA method for Anti-TPO Ab | Clinical hyperthyroidism: TSH < 0.1 mIU/L and FT4 > 4.5 ng/dL; clinical hypothyroidism: TSH > 10 mIU/L or TSH > 2.5 mIU/L and FT4I < 1 ng/dL; subclinical hypothyroidism: elevated TSH (2.5–10 mIU/L) and normal FT4I (1–4.5 ng/dL); Anti-TPO Ab-positive: >  50 mIU/L | 9 |
[31] | Zangeneh M, 2015 | 2011–12 | Kermanshah | 1200 | < 16 week | ELISA method | Reference renege for TSH is 0.27–4.2 mIU/L and for FT4I is 5.13–14.6 | 7 |
[32] | Maleki N, 2014 | 2011–3 | Bushehr | 313 | 24–28 week | RIA method for FT4 and FT3 | Reference renege in the first, second and third trimesters for TSH 0.1–2.5 mIU/L, 0.2–3.0 mIU/L; and 0.3–3.0 mIU/L, respectively. | 7 |
[33] | Sarkhail P, 2016 | 2004–06 | Tehran | 120 | All trimester | RIA method for TT4 and TT3 and IRMA for TSH | Reference renege in the first, second and third trimesters are TSH (0.2–3.9, 0.5–4.1, and 0.6–4.1 mIU/l); TT4 (8.2–18.5, 10.1–20.6, and 9–19.4 ≥ g/dL); and TT3 (137–278, 154–327, and 137–323 ng/dL), respectively. | 7 |
[34] | Mellati Ali Avesti SF, 2003 | 2002 | Zanjan | 500 | First trimester | IRMA method for TSH and RIA method for FT4 | NR | 6 |