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Table 3 Results of primary and subgroup meta-analyses by outcome

From: A systematic review and time-response meta-analysis of the optimal timing of elective caesarean sections for best maternal and neonatal health outcomes

Meta-analyses

Studies

References

Patients n

Shape of association

Risk ratio

95% CI

I2

NICU admission all

14

[25, 37, 39, 51, 52, 54,55,56, 60, 62, 63, 65, 68, 69]

898,272

Linear dose-responsea

0.63

0.56–0.71

95.4

Neonatal death

4

[37, 40, 62, 65]

533,880

U-Shapeb

< 39: 0.59

≥39: 2.09

0.43–0.83

1.18–3.70

77.5

Respiratory morbidity

9

[51, 53, 55, 57, 58, 61, 64, 65, 68]

57,693

Linear dose-responsea

0.64

0.51–0.79

95.2

Hospitalization ≥5 days

5

[38, 62, 65, 68, 69]

59,331

U-Shapeb

< 39 0.52

≥39 2.00

0.36–0.75

1.40–2.86

96.2

Sepsis

4

[37, 52, 65, 68]

42,381

U-Shapeb

< 39 0.55

≥39 3.57

0.44–0.67

1.87–6.78

21.8

Hypoglycemia

6

[25, 38, 60, 65, 68, 69]

46,367

Linear dose-responsea

0.84

0.79–0.91

0.0

Apgar Score < 7

5

[39, 56, 60, 65, 69]

805,274

Linear dose-responsea

0.90

0.69–1.17

65.7

Jaundice

5

[56, 60, 65, 68, 69]

32,109

Linear dose-responsea

0.71

0.66–0.77

53.7

Respiratory distress syndrome

5

[37, 59, 60, 65, 69]

43,888

Linear dose-responsea

0.60

0.54–0.67

45.0

Transient tachypnea of the newborn

5

[37, 55, 59, 60, 65]

40,766

Linear dose-responsea

0.68

0.54–0.86

84.1

Pneumothorax

4

[44, 59, 60, 67]

25,121

Binary (37 + 38 WG vs. ≥39 WG)c

0.99

0.03–39.19

72.0

Maternal hysterectomy

2

[37, 52]

18,662

Binary (37 + 38 WG vs. ≥39 WG)c

1.10

0.03–39.35

0.0

Maternal blood transfusion

2

[37, 60]

15,162

Binary (37 + 38 WG vs. ≥39 WG)c

1.21

0.02–65.67

30.0

Meta-analyses of subgroups

 NICU admission only ERCS

4

[37, 39, 54, 60]

792,107

Linear dose-responsea

0.66

0.65–0.67

0.0

 NICU death only repeat CS

2

[37, 40]

497,917

U-Shapeb

< 39 0.67

≥39 1.68

0.51–0.87

1.07–2.65

0.0

  1. NICU Neonatal Intensive Care Unit; WG Week of gestation
  2. a Starting at 37 WG, RR for each additional WG
  3. b Starting at 39 WG, RR for each fewer WG and RR for each additional WG
  4. c Comparison of two timeframes; 37 + 38 WG = 37 + (0–6) + 38 + (0–6), 39 WG = 39 + 0