Does growth hormone supplementation improve oocyte competence and IVF outcomes in patients with poor embryonic development? A randomized controlled trial

Table 2 Comparison of embryology data between the growth-hormone (GH)-treated and control groups

	GH (n = 107)	Control (n = 51)	P-value	MD (95% CI)
No. of oocytes retrieved per patient	10.29 ± 5.92	8.16 ± 4.17	0.022^a	2.130 (0.528–3.732)
No. of metaphase II oocytes	9.08 ± 5.83	7.49 ± 3.98	0.040^a	1.590 (0.036–3.144)
No. of 2PN oocytes	6.77 ± 4.51	5.45 ± 3.30	0.049^a	1.320 (0.075–2.565)
Fertilization rate (%)	724/972 (74.49%)	278/382 (74.73%)	0.564^b
No. of cleaved embryos	6.73 ± 4.25	5.29 ± 3.23	0.033^a	1.440 (0.242–2.638)
Cleavage rate (%)	693/724 (95.72%)	270/278 (97.12%)	0.397^b
No. of transferable embryos	3.30 ± 2.14	2.96 ± 1.97	0.400^a
Transferable embryo rate (%)	340/693 (49.06%)	151/270 (55.93%)	0.065 ^b
No. of transferred embryos per ET	1.92 ± 0.40	1.87 ± 0.40	0.464^a
Cycles reaching ET rate (%)	91/107 (85.05%)	45/51 (88.24%)	0.768 ^b
Reason for lack of ET
OHSS, freezing of all embryos, n	12	4
Failed fertilization, n	1	1
Failed cleavage, n	3	1

Categorical variables are presented as proportion (%). Continuous variables are presented as mean ± SD
For comparisons of dichotomous variables, χ² test was used. For comparisons of continuous variables, Student’s t test was used
CI confidence interval, ET embryo transfer, MD mean difference, OHSS ovarian hyperstimulation
Fertilization rate: No. of 2PN oocytes/ No. of metaphase II oocytes; Cleavage rate: No. of cleaved embryos/ No. of 2PN oocytes; Transferable embryo rate: No. of transferable embryos/ No. of cleaved embryos
^a, Student’s t test; ^b, χ² test

ISSN: 1471-2393