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Table 3 Comparison on maternal plasma TAMO concentration between preeclampsia and control groups

From: Association between risk of preeclampsia and maternal plasma trimethylamine-N-oxide in second trimester and at the time of delivery

Group

T2 plasma TMAO (median (Q1, Q3), μg/m3)

TD plasma TMAO (median (Q1, Q3), μg/m3)

Change of TMAO (median (Q1, Q3), μg/m3)

Control (N = 198)

84.05 (60.44, 113.90)

134.96 (78.10, 202.15)

53.71(− 2.60, 115.52)

PE (N = 66)

92.40 (53.80, 126.36)

151.01 (103.45, 280.48)

57.47 (8.32, 211.50)

 Difference with control (95%CI)a

7.45(− 6.92, 21.83)

33.25 (8.54, 57.97)

24.36(−9.11, 57.84)

pb

0.296

0.010

0.167

EOPE (N = 17)

72.30 (54.58, 109.66)

370.00 (132.37, 514.86)

297.70 (34.63, 454.05)

 Difference with control (95%CI)a

−2.62(−23.44, 18.19)

191.25 (52.33,330.16)

196.49 (63.67, 329.31)

pb

0.791

< 0.001

< 0.001

LOPE (N = 49)

93.30(53.80, 149.00)

138.71 (101.66, 207.00)

30.63 (0.00, 122.42)

 Difference with control (95%CI)a

12.33(−5.03, 29.70)

14.55(−11.16, 40.28)

−4.66(−37.17, 27.84)

pb

0.162

0.245

0.766

Mild PE (N = 41)

103.45 (53.80, 149.00)

138.71 (100.68, 207.08)

34.63(−1.03, 130.69)

 Difference with control (95%CI)a

13.71(−6.17, 33.60)

15.00(−13.00, 43.02)

−3.70(−40.44, 33.04)

pb

0.170

0.275

0.819

Sever PE (N = 25)

85.10 (54.60, 109.66)

168.24 (128.14, 476.65)

85.23 (27.96, 340.35)

 Difference with control (95%CI)a

0.15(−17.69, 17.99)

78.93 (26.88, 130.98)

88.10 (21.03, 155.17)

pb

0.976

0.002

0.006

  1. a 95% CIs were estimated with the Hodges-Lehmann method
  2. b Based on Wilcoxon rank-sum test
  3. Abbreviation: TMAO trimethylamine-N-oxide; PE preeclampsia; EOPE early onset preeclampsia; LOPE late onset preeclampsia; T2 the second trimester; TD the time of delivery; Q1 first quartile; Q3 third quartile; CI confident interval