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Table 3 Association of pre-eclampsia in women with a singleton or twin pregnancy

From: Maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study

  

PE

OR (95% CI)

 

Mediation

OR (95% CI)

 

Singleton

Twin

 

sFLT / PGF ratio

Basic model

Reference

2.90 (2.03 to 4.16)

Direct effect

2.18 (1.38 to 3.43)

Confounder model

Reference

3.63 (1.76 to 7.48)

Direct effect

2.63 (1.05 to 6.57)

Placenta model

Reference

6.76 (2.81 to 16.24)

Direct effect

4.35 (1.43 to 13.22)

  1. Data are represented as the odds ratio (OR) with the 95% confidence interval (CI) and are based on logistic regression models. The represented direct effect is the OR of women with twin pregnancies to develop PE if you take the mediating role of sFLT and PGF in early pregnancy into account. Basic model: adjusted for maternal age at intake and gestational age at birth. Confounder model: basic model additionally adjusted for ethnicity, educational level, parity, smoking, method of conception and BMI at intake. Placenta model: confounder model additionally adjusted for placental weight. Abbreviations: PE Pre-eclampsia, sFLT Soluble fms-like tyrosine kinase 1, PGF Placental growth factor
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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