Low birthweight in term singletons mediates the association between maternal smoking intensity exposure status and immediate neonatal intensive care unit admission: the E-value assessment

Table 3 Adjusted odds ratios for neonatal intensive care unit admission associated with total effect, controlled direct, natural direct and natural indirect effects, and percentage mediated through low birthweight

Smoking Intensity Status	Total Effect		Controlled Direct Effect		Natural Direct Effect		Natural Indirect Effect		Percentage Mediated
Smoking Intensity Status	aOR	95% CI	aOR	95% CI	aOR	95% CI	aOR	95% CI	%	95% CI
Quitter-Low	1.14	1.08, 1.19	1.13	1.07, 1.19	1.12	1.06, 1.18	1.02	1.01, 1.02	13.35	6.66, 20.04
Quitter-High	1.28	1.20, 1.37	1.24	1.15, 1.33	1.24	1.16, 1.33	1.03	1.02, 1.04	13.89	8.33, 19.45
Maintainer-Low	1.38	1.34, 1.43	1.35	1.30, 1.40	1.33	1.28, 1.37	1.04	1.04, 1.05	15.14	12.52, 17.77
Maintainer-High	1.68	1.63, 1.73	1.58	1.53, 1.63	1.56	1.51, 1.61	1.08	1.07, 1.09	17.58	15.48, 19.67
Reducer	1.44	1.37, 1.51	1.40	1.33, 1.47	1.37	1.31, 1.44	1.05	1.04, 1.06	15.58	11.81, 19.36
Increaser	1.48	1.18, 1.79	1.44	1.13, 1.76	1.42	1.12, 1.72	1.04	1.00, 1.09	12.91	−0.91, 26.73

aOR adjusted odds ratio, CI confidence interval; Low intensity smoking: < 10 cigarettes/day; High intensity smoking: ≥10 cigs/day; Adjusted for: maternal race/ethnicity, age, education, marital status, and parity. Total effect = natural direct + natural indirect effect

ISSN: 1471-2393